Comparing Different Routes and Doses of Phytonadione (Vitamin K) for Reversing Warfarin Treated Patients With Hip Fracture Before Surgery
- Registration Number
- NCT00905229
- Lead Sponsor
- HaEmek Medical Center, Israel
- Brief Summary
It is well known that femoral neck fractures carry a significant increase in patients' mortality and that surgical intervention is the preferred treatment.
Any delay in operating on such patients would inevitably increase their risk of developing complications. One of the reasons for such unintentional delay would be the hypercoagulative status of patients taking warfarin. The CHEST 2008 guidelines suggest reversing warfarin with Vitamin K for patients who need urgent operation. The aim of this study is to compare different roots and doses of Vitamin K.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- WITHDRAWN
- Sex
- All
- Target Recruitment
- Not specified
Inclusion Criteria
- hip fracture patients on warfarin
Exclusion Criteria
- pregnancy
- vitamin k sensitivity
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description PO (by mouth) Phytonadione 2.5 mg P.O Vitamin K IV (intravenous ) Phytonadione 0.5 mg IV Vitamin K
- Primary Outcome Measures
Name Time Method International normalized ratio (INR) </= 1.2 3 days
- Secondary Outcome Measures
Name Time Method Bleeding 6 weeks Complications 6 weeks
Trial Locations
- Locations (1)
Haemek Medical Center
🇮🇱Afula, Israel