NCT00905229撤回不适用
Comparing Different Routes and Doses of Phytonadione (Vitamin K) for Reversing Warfarin Treated Patients With Hip Fracture Before Surgery
适应症
干预措施
相关药物
试验速览
- 阶段
- 不适用
- 状态
- 撤回
- 试验地点
- 1
- 主要终点
- International normalized ratio (INR) </= 1.2
研究概览
简要总结
It is well known that femoral neck fractures carry a significant increase in patients' mortality and that surgical intervention is the preferred treatment.
Any delay in operating on such patients would inevitably increase their risk of developing complications. One of the reasons for such unintentional delay would be the hypercoagulative status of patients taking warfarin. The CHEST 2008 guidelines suggest reversing warfarin with Vitamin K for patients who need urgent operation. The aim of this study is to compare different roots and doses of Vitamin K.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —(Adult, Older Adult)
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •hip fracture patients on warfarin
排除标准
- •pregnancy
- •vitamin k sensitivity
研究组 & 干预措施
PO (by mouth)
Active Comparator
2.5 mg P.O Vitamin K
干预措施: Phytonadione (Drug)
IV (intravenous )
Active Comparator
0.5 mg IV Vitamin K
干预措施: Phytonadione (Drug)
结局指标
主要结局
International normalized ratio (INR) </= 1.2
时间窗: 3 days
次要结局
- Bleeding(6 weeks)
- Complications(6 weeks)
研究者
研究点 (1)
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