The Migrainous Brain: a Prospective Research for Longitudinal Changes of Brain Networks in Migraine
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Migraine
- Sponsor
- Samsung Medical Center
- Enrollment
- 100
- Locations
- 1
- Primary Endpoint
- Core fMRI features for migraine brain
- Last Updated
- 6 years ago
Overview
Brief Summary
The purpose of this study is to identify a core fMRI feature that determines migrainous brain and plastic fMRI features that changes with longitudinal courses of migraine.
Detailed Description
Migraine is associated with functional alterations in specific brain networks. The investigators aimed to identify network abnormalities which remain unchanged throughout the longitudinal course of migraine. The investigators also aimed to identify networks which change in association with changes in migraine frequency and associated psychiatric conditions. The investigators expect these can serve as neuroimaging biomarkers for diagnosis of migraine brain and monitoring of disease severity.
Investigators
Chin-Sang Chung
MD, PhD, Professor of neurology
Samsung Medical Center
Eligibility Criteria
Inclusion Criteria
- •Migrainuers :
- •age 18-50 years
- •migraine with or without aura as defined by the third edition of the International Classification of Headache Disorders (ICHD-3 beta)
- •if female, before the onset of menopausal
- •age 18-50 years
- •no headache disorder other than Infrequent episodic tension-type headache as defined by the ICHD-3 beta
- •Exclusion criteria:
- •contraindicated to MRI
- •require sedation treatment because of claustrophobia when performing MRI
- •predicted to be unable to write the headache diary due to cognitive decline
Exclusion Criteria
- Not provided
Outcomes
Primary Outcomes
Core fMRI features for migraine brain
Time Frame: 1-year follow-up (2nd year)
Among significant networks identified by ICA, we will identify altered networks which remain unchanged in follow-up resting-state fMRI in 1 year.
Secondary Outcomes
- Dynamic fMRI features for disease severity(1-year follow-up (2nd year))
- Candidate fMRI features for migraine(Baseline (1st year))