Effect of topical and oral Resveratrol on skin health, condition and visible signs of ageing, in healthy ageing females.

Phase 3

Completed

• Conditions: Skin health; Visible signs of skin ageing; Skin - Normal skin development and function; Skin condition - pores, sebum, wrinkle, pigment condition, moisture, elasticity, skin toneand skin temperature; Skin condition - pores, sebum, wrinkle, pigment condition, moisture, elasticity, skin tone; and skin temperature

• Registration Number: ACTRN12621000709842
• Lead Sponsor: RDC Clinical Pty Ltd

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2021-06-08
• Study Completion: 2022-11-29
• Last Update Posted: 27 March 2023

Recruitment & Eligibility

• Status: Completed
• Sex: Female
• Target Recruitment: 136

Inclusion Criteria

•Females aged 40 years and above
•Otherwise healthy
•Agree not to change standard skincare routine
•Able to provide informed consent
•Agree not to undertake another clinical trial while enrolled in this trial

Exclusion Criteria

•Clinically significant medical conditions including, but not limited to, cardiovascular, neurological, psychiatric, renal, gastrointestinal, immunological, endocrine (including uncontrolled diabetes or thyroid disease) or haematological abnormalities that are uncontrolled
•Currently taking resveratrol or using resveratrol cream
•Cosmetic surgery and procedures, including Botox and other injectables, microdermabrasion, laser treatments
•Active smokers, nicotine use, alcohol or drug (prescription or illegal substances) abuse
•Chronic past and/or current alcohol use (Greater than 14 alcoholic drinks week)
•Known pregnant or lactating woman
•Allergies or hypersensitivity to resveratrol
•Any condition which in the opinion of the investigator makes the participant unsuitable for inclusion

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Change in wrinkles (fine and deep lines) as composite outcome -Measured using the A-One Smart Pro skin analysis system[Baseline, Week 4 and Week 8 (primary endpoint) post- commencement of intervention ]

Secondary Outcome Measures

Name	Time	Method
Other Skin characteristics measured as a composite outcome (including pore, sebum, elasticity, tone and pigment condition. The attached probe measures skin temperature and moisture) – as measured by A-One Smart Pro skin analysis system[Baseline, week 4 and Week 8 post- commencement of intervention ];Change in Subject self-assessment questionnaire (Designed for this study and consists of 17 questions related to overall satisfaction with the product and specific facial and skin properties) [Week 4 and Week 8 post- commencement of intervention ];Biochemical Measurements (Oxidative stress markers, resveratrol concentration (free), metabolites (conjugated sulphate and glucuronidase)) as measured in plasma in composite outcome[Baseline, Week 4 and Week 8 post- commencement of intervention ];Change in photography as assessed by visual assessment (pigment and skin condition) [Baseline, Week 4 and Week 8 post- commencement of intervention ]