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Clinical Trials/NCT04081155
NCT04081155CompletedNot Applicable

Effect of Positive End-expiratory Pressure(PEEP) on Regional Ventilation and Perfusion Estimated by Indicator-based Electrical Impedance Tomography(EIT) Method in Critically Ill Patients With Mechanical Ventilation

Yun Long1 site in 1 country33 target enrollmentStarted: January 1, 2019Last updated:
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Conditions

Trial Snapshot

Phase
Not Applicable
Status
Completed
Sponsor
Enrollment
33
Locations
1
Primary Endpoint
lung regional perfusion distribution
Study OverviewStudy DesignEligibility CriteriaOutcomesInvestigatorsSitesRecords & IdentifiersSimilar Trials

Study Overview

Brief Summary

Investigate effects of PEEP on pulmonary regional ventilation and perfusion assessed by EIT

Detailed Description

  1. When the research team was available, adult patients within 7days who were sequentially admitted to the Department of Critical Care Medicine and required central venous catheters and mechanically ventilation were eligible for the study.
  2. Written informed consent was obtained from all patients or next of kin before data were included in the study.
  3. Information collected at enrollment included demographic characteristics, such as age, sex.
  4. The blood pressure（BP）,heart rate（HR）, pulse O2（SpO2）,tidal volume and lung regional ventilation and perfusion were collected at PEEP 0 centimeter H2O column and PEEP 12-15 centimeter H2O column.
  5. Indicator-based EIT method: rapidly inject 10ml 10% Sodium chloride（NaCL） through central venous catheter during a 8s respiratory hold, and the curve of impedence change was collected by EIT machine

Study Design

Study Type
Observational
Observational Model
Case Only
Time Perspective
Prospective

Eligibility Criteria

Ages
18 Years to — (Adult, Older Adult)
Sex
All
Accepts Healthy Volunteers
No

Inclusion Criteria

  • •have been placed central venous catheter based on patient's condition
  • •Under mechanically ventilation
  • •Under sedation and control ventilation mode

Exclusion Criteria

  • •Pneumothorax
  • •Severe chest wall wound
  • •Severe hypernatremia

Outcomes

Primary Outcomes

lung regional perfusion distribution

Time Frame: Hour 1

lung regional perfusion distribution measured by EIT

lung regional ventilation distribution

Time Frame: Hour 1

lung regional ventilation distribution measured by EIT

Secondary Outcomes

No secondary outcomes reported

Investigators

Sponsor
Yun Long
Sponsor Class
Other
Responsible Party
Sponsor Investigator
Principal Investigator

Yun Long

the director of the intensive care medicine

Peking Union Medical College Hospital

Study Sites (1)

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