NCT04081155CompletedNot Applicable
Effect of Positive End-expiratory Pressure(PEEP) on Regional Ventilation and Perfusion Estimated by Indicator-based Electrical Impedance Tomography(EIT) Method in Critically Ill Patients With Mechanical Ventilation
Yun Long1 site in 1 country33 target enrollmentStarted: January 1, 2019Last updated:
Conditions
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Enrollment
- 33
- Locations
- 1
- Primary Endpoint
- lung regional perfusion distribution
Study Overview
Brief Summary
Investigate effects of PEEP on pulmonary regional ventilation and perfusion assessed by EIT
Detailed Description
- When the research team was available, adult patients within 7days who were sequentially admitted to the Department of Critical Care Medicine and required central venous catheters and mechanically ventilation were eligible for the study.
- Written informed consent was obtained from all patients or next of kin before data were included in the study.
- Information collected at enrollment included demographic characteristics, such as age, sex.
- The blood pressure(BP),heart rate(HR), pulse O2(SpO2),tidal volume and lung regional ventilation and perfusion were collected at PEEP 0 centimeter H2O column and PEEP 12-15 centimeter H2O column.
- Indicator-based EIT method: rapidly inject 10ml 10% Sodium chloride(NaCL) through central venous catheter during a 8s respiratory hold, and the curve of impedence change was collected by EIT machine
Study Design
- Study Type
- Observational
- Observational Model
- Case Only
- Time Perspective
- Prospective
Eligibility Criteria
- Ages
- 18 Years to — (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •have been placed central venous catheter based on patient's condition
- •Under mechanically ventilation
- •Under sedation and control ventilation mode
Exclusion Criteria
- •Pneumothorax
- •Severe chest wall wound
- •Severe hypernatremia
Outcomes
Primary Outcomes
lung regional perfusion distribution
Time Frame: Hour 1
lung regional perfusion distribution measured by EIT
lung regional ventilation distribution
Time Frame: Hour 1
lung regional ventilation distribution measured by EIT
Secondary Outcomes
No secondary outcomes reported
Investigators
Yun Long
the director of the intensive care medicine
Peking Union Medical College Hospital
Study Sites (1)
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