NCT04081155已完成不适用
Effect of Positive End-expiratory Pressure(PEEP) on Regional Ventilation and Perfusion Estimated by Indicator-based Electrical Impedance Tomography(EIT) Method in Critically Ill Patients With Mechanical Ventilation
Yun Long1 个研究点 分布在 1 个国家目标入组 33 人开始时间: 2019年1月1日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 33
- 试验地点
- 1
- 主要终点
- lung regional perfusion distribution
研究概览
简要总结
Investigate effects of PEEP on pulmonary regional ventilation and perfusion assessed by EIT
详细描述
- When the research team was available, adult patients within 7days who were sequentially admitted to the Department of Critical Care Medicine and required central venous catheters and mechanically ventilation were eligible for the study.
- Written informed consent was obtained from all patients or next of kin before data were included in the study.
- Information collected at enrollment included demographic characteristics, such as age, sex.
- The blood pressure（BP）,heart rate（HR）, pulse O2（SpO2）,tidal volume and lung regional ventilation and perfusion were collected at PEEP 0 centimeter H2O column and PEEP 12-15 centimeter H2O column.
- Indicator-based EIT method: rapidly inject 10ml 10% Sodium chloride（NaCL） through central venous catheter during a 8s respiratory hold, and the curve of impedence change was collected by EIT machine
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •have been placed central venous catheter based on patient's condition
- •Under mechanically ventilation
- •Under sedation and control ventilation mode
排除标准
- •Pneumothorax
- •Severe chest wall wound
- •Severe hypernatremia
结局指标
主要结局
lung regional perfusion distribution
时间窗: Hour 1
lung regional perfusion distribution measured by EIT
lung regional ventilation distribution
时间窗: Hour 1
lung regional ventilation distribution measured by EIT
次要结局
未报告次要终点
研究者
Yun Long
the director of the intensive care medicine
Peking Union Medical College Hospital
研究点 (1)
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