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临床试验/NCT04081155
NCT04081155已完成不适用

Effect of Positive End-expiratory Pressure(PEEP) on Regional Ventilation and Perfusion Estimated by Indicator-based Electrical Impedance Tomography(EIT) Method in Critically Ill Patients With Mechanical Ventilation

Yun Long1 个研究点 分布在 1 个国家目标入组 33 人开始时间: 2019年1月1日最近更新:
适应症

试验速览

阶段
不适用
状态
已完成
发起方
入组人数
33
试验地点
1
主要终点
lung regional perfusion distribution

研究概览

简要总结

Investigate effects of PEEP on pulmonary regional ventilation and perfusion assessed by EIT

详细描述

  1. When the research team was available, adult patients within 7days who were sequentially admitted to the Department of Critical Care Medicine and required central venous catheters and mechanically ventilation were eligible for the study.
  2. Written informed consent was obtained from all patients or next of kin before data were included in the study.
  3. Information collected at enrollment included demographic characteristics, such as age, sex.
  4. The blood pressure(BP),heart rate(HR), pulse O2(SpO2),tidal volume and lung regional ventilation and perfusion were collected at PEEP 0 centimeter H2O column and PEEP 12-15 centimeter H2O column.
  5. Indicator-based EIT method: rapidly inject 10ml 10% Sodium chloride(NaCL) through central venous catheter during a 8s respiratory hold, and the curve of impedence change was collected by EIT machine

研究设计

研究类型
Observational
观察模型
Case Only
时间视角
Prospective

入排标准

年龄范围
18 Years 至 —(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • have been placed central venous catheter based on patient's condition
  • Under mechanically ventilation
  • Under sedation and control ventilation mode

排除标准

  • Pneumothorax
  • Severe chest wall wound
  • Severe hypernatremia

结局指标

主要结局

lung regional perfusion distribution

时间窗: Hour 1

lung regional perfusion distribution measured by EIT

lung regional ventilation distribution

时间窗: Hour 1

lung regional ventilation distribution measured by EIT

次要结局

未报告次要终点

研究者

发起方
Yun Long
申办方类型
Other
责任方
Sponsor Investigator
主要研究者

Yun Long

the director of the intensive care medicine

Peking Union Medical College Hospital

研究点 (1)

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