A Trial to Compare American Heart Association (AHA) and Simple (SIM)Method to Give Adenosine to Treat Supra-ventricular Tachycardia (SVT)

Phase 3

Completed

• Conditions: Supra-ventricular Tachycardia
• Interventions: Drug: Adenosine

• Registration Number: NCT04392362
• Lead Sponsor: University of Pretoria

Brief Summary

Study to compare non inferiority of giving adenosine with the simplified method vs the AHA method

Detailed Description

tle: A randomised controlled trial of the standard versus a simplified adenosine administration method in the treatment of adult patients with supra- ventricular tachycardia (SVT

Study Timeline

• Study Start: 2018-04-01
• Study First Submitted: 2020-04-21
• Study First Submitted QC: 2020-05-12
• Study First Posted: 2020-05-18
• Primary Completion: 2020-12-16
• Study Completion: 2020-12-16
• Results First Submitted: 2021-05-06
• Status Verified: 2021-06
• Results First Submitted QC: 2021-06-03
• Last Update Submitted: 2021-06-03
• Results First Posted: 2021-06-25
• Last Update Posted: 2021-06-25

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

• Svt
• normal blood pressure
• normal mentation
• Give consent

Exclusion Criteria

• recent coffee
• Allergy to adenosine
• Asthma
• cardiac operations

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Intervention group	Adenosine	Method of giving adenosine at 6mg then 12mg repeated twice to abort svt Intervention is giving the drug in a simplified method mixing it with 20 ml saline as a whole flush
Control group	Adenosine	Giving adenosine Ising the recommended AHA two syringe method

Primary Outcome Measures

Name	Time	Method
The Number of Patients With First Dose Successful Termination of the Supraventricular Tachycardia to a Sinus Rhythm of Less Than 140 With the AHA Versus a Simplified Method of Adenosine Administration	10 seconds	The primary outcome is the rhythm of conversion to a sinus rhythm less than 140 beat per minute.

Trial Locations

Locations (1)

Steve Biko hospital; 🇿🇦 Pretoria, Gauteng, South Africa