comparative study of antimicrobial efficacy of panchavalkal kwatha and povidone iodine for surgical site preparation on the human skin flora
试验速览
- 阶段
- 2 期
- 状态
- 尚未招募
- 发起方
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- Erythema
研究概览
简要总结
The skin flora of patients is one of the most important factors in pathogenesis of surgical site infection. There are two type of skin flora-
Resident flora-Represents the organisms that always present on the whole skin surface including those in the deeper parts of the skin such as the ducts of sebaceous and sweat gland follicles. Flora consist predominantly Staph. epidermis, micrococci,diphtheroids
Transient flora- Wider rang of organisms come in contact with the superficial aspect of skin from the environment, another person or from the persons own alimentary tract. Eg.Staphylococcus.aureus , E.coli ,Klebsiella
Microorganisms are found all over the skin surface but species vary with anatomical sites-
Dry Body sites mainly includes forearm,hands,leg and feet. Eg- coagulase negative staphy.epidermis and staphy.horminis.
Moist sites includes skin folds, beneath breast,elbow crease,in between the groin. These are mainly cornybacterium
Sebaceous sites includes head, neck, trunk area where oily substance sebum allows cutibacterium to thrive, some deodex mites and fungus Malasezzia also congregate in the oily.
area of faces
Microbes that exist on the skin are primarily gram positive.
Staphylococcus epidermis is found in 85%- 100% of normal skin.
Staphylococcus aureus is carried by 5%-25% of normal individuals.
Propionibacterium is normal flora in 45%-100%
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 盲法
- None
入排标准
- 年龄范围
- 20.00 Year(s) 至 50.00 Year(s)(—)
- 性别
- All
入选标准
- •Patients prepared for elective abdominal surgeries in Department of Prasuti Tantra SSH BHU and Department of Shalya Tantra SSH BHU.
排除标准
- •Patients having skin infection on lower abdominal area Patients having a active untreated STDs Patients having any severe systemic diseases where healing may be compromised Patients having severe anemia Povidone iodine sensitive patients Patient with irregular follow ups.
结局指标
主要结局
Erythema
时间窗: 2 Followup 2 week | FU1 on 3rd day | FU 2 on stitch removal
pruritis
时间窗: 2 Followup 2 week | FU1 on 3rd day | FU 2 on stitch removal
scaliness
时间窗: 2 Followup 2 week | FU1 on 3rd day | FU 2 on stitch removal
pain
时间窗: 2 Followup 2 week | FU1 on 3rd day | FU 2 on stitch removal
oedema
时间窗: 2 Followup 2 week | FU1 on 3rd day | FU 2 on stitch removal
Minimum Inhibition Concentration
时间窗: 2 Followup 2 week | FU1 on 3rd day | FU 2 on stitch removal
Microorganisms growth/Microbial load
时间窗: 2 Followup 2 week | FU1 on 3rd day | FU 2 on stitch removal
Surgical Outcomes
时间窗: 2 Followup 2 week | FU1 on 3rd day | FU 2 on stitch removal
Based on Subjective and Objective criteria and
时间窗: 2 Followup 2 week | FU1 on 3rd day | FU 2 on stitch removal
Laboratory investigations
时间窗: 2 Followup 2 week | FU1 on 3rd day | FU 2 on stitch removal
Skin tolerability
时间窗: 2 Followup 2 week | FU1 on 3rd day | FU 2 on stitch removal
次要结局
- Decreased microbial load(2followup 2 week)
研究者
Dr Kumari Sarita
Banaras Hindu University
