Experimental human pneumococcal carriage

Not Applicable

Completed

• Conditions: Specialty: Infectious diseases and microbiology, Primary sub-specialty: Antimicrobial therapy; Infections and Infestations; Pneumococcal infection

• Registration Number: ISRCTN85403723
• Lead Sponsor: Royal Liverpool Hospital

Brief Summary

2013 Results article in http://www.ncbi.nlm.nih.gov/pubmed/23439027 results 2013 Results article in http://www.ncbi.nlm.nih.gov/pubmed/23555269 results 2013 Results article in http://www.ncbi.nlm.nih.gov/pubmed/23370916 results 2014 Results article in http://www.ncbi.nlm.nih.gov/pubmed/24995531 results 2014 Results article in http://www.ncbi.nlm.nih.gov/pubmed/25671106 results 2016 Results article in http://www.ncbi.nlm.nih.gov/pubmed/27403678 results 2020 Results article in https://doi.org/10.1371/journal.pone.0229558 (added 12/09/2023) 2018 Results article in https://doi.org/10.1186/s41479-018-0048-3 (added 12/09/2023)

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Completion: 2013-01-04
• Study Start: 2016-08-25
• Last Update Posted: 26 September 2023

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 200

Inclusion Criteria

1. Adults aged 18-60 years old
2. Fluent English spoken

Exclusion Criteria

1. Close contact with young children, elderly or immunocompromised individuals (either at work or home)
2. Asthma or pre-existing lung disease
3. Cigarette smoking of greater than 20 pack years
4. Chronic illness
5. Pregnancy
6. Penicillin allergy

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Presence of pneumococci is measured using classical culture methods in nasal wash at 48 hours and/or 7 days following inoculation.

Secondary Outcome Measures

Name	Time	Method
o secondary outcome measures