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Clinical Trials/NL-OMON32861
NL-OMON32861
Completed
Not Applicable

The influence of depression and neuroinflammation on the progression of mild cognitive impairment to dementia: PET imaging of amyloid deposition and microglia activation - Neurobiology of mild cognitive impairment

niversitair Medisch Centrum Groningen0 sites48 target enrollmentTBD
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Conditionslate onset depressionMild cognitive impairment1004225810012272

Overview

Phase
Not Applicable
Intervention
Not specified
Conditions
late onset depression
Sponsor
niversitair Medisch Centrum Groningen
Enrollment
48
Status
Completed
Last Updated
last year
OverviewInvestigatorsEligibility CriteriaOutcomesSimilar Trials

Overview

Brief Summary

No summary available.

Registry
who.int
Start Date
TBD
End Date
TBD
Last Updated
last year
Study Type
Observational invasive

Investigators

Eligibility Criteria

Inclusion Criteria

  • •Informed consent
  • •Aged between 50\-80 years
  • •Assigned by physician as competent to participate in the study
  • •Inclusion groups:
  • •o Fulfilling the criteria for healthy volunteers
  • •o Fulfilling the criteria for late onset depression
  • •o Fulfilling the criteria for MCI
  • •o Fulfilling the criteria for both late onset depression and MCI

Exclusion Criteria

  • •History of major psychiatric disorders such as schizophrenia and bipolar disorder and previous unipolar depression
  • •History of head trauma
  • •Ischemic cerebrovascular disease, determined by MRI
  • •Major medical illnesses such as coronary heart disease, diabetes and cancer
  • •Chronic inflammatory disease such as rheumatoid arthritis, osteoarthritis, chronic obstructive pulmonary disease, psoriasis, etc.
  • •Use of anti\-inflammatory medication such as non\-steroidal anti\-inflammatory drugs (NSAID) and corticosteroids during a week before PET scan
  • •The use benzodiazepines a week before the PET scan
  • •The use of statins, acetylcholinesterase inhibitors, warfarin and digoxin
  • •History of substance abuse such as alcohol and nicotine (smoking) within the last 6 months
  • •Presence of dementia

Outcomes

Primary Outcomes

Not specified

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