NL-OMON32861CompletedNot Applicable
The influence of depression and neuroinflammation on the progression of mild cognitive impairment to dementia: PET imaging of amyloid deposition and microglia activation - Neurobiology of mild cognitive impairment
Conditions
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Enrollment
- 48
Study Overview
Brief Summary
No summary available.
Study Design
- Study Type
- Observational
Eligibility Criteria
- Ages
- 18 to 99 (—)
Inclusion Criteria
- •Informed consent
- •Aged between 50-80 years
- •Assigned by physician as competent to participate in the study
- •Inclusion groups:
- •o Fulfilling the criteria for healthy volunteers
- •o Fulfilling the criteria for late onset depression
- •o Fulfilling the criteria for MCI
- •o Fulfilling the criteria for both late onset depression and MCI
Exclusion Criteria
- •History of major psychiatric disorders such as schizophrenia and bipolar disorder and previous unipolar depression
- •History of head trauma
- •Ischemic cerebrovascular disease, determined by MRI
- •Major medical illnesses such as coronary heart disease, diabetes and cancer
- •Chronic inflammatory disease such as rheumatoid arthritis, osteoarthritis, chronic obstructive pulmonary disease, psoriasis, etc.
- •Use of anti-inflammatory medication such as non-steroidal anti-inflammatory drugs (NSAID) and corticosteroids during a week before PET scan
- •The use benzodiazepines a week before the PET scan
- •The use of statins, acetylcholinesterase inhibitors, warfarin and digoxin
- •History of substance abuse such as alcohol and nicotine (smoking) within the last 6 months
- •Presence of dementia
- •Any patients with MRI contradictions such as metal implantations and pacemakers
- •Malnutrition (vitamin deficiency) or obesity (BMI > 30)
Investigators
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