The effect of hypothalamic temperature setpoint inhibition at a central and peripheral level on exertional elevations of core body temperature.

Completed

• Conditions: Systemisch: thermoregulatie; Exertional hyperthermia; overheating during exercise

• Registration Number: NL-OMON38258
• Lead Sponsor: niversitair Medisch Centrum Sint Radboud

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Completion: 2016-01-12
• Last Update Posted: 29 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 16

Inclusion Criteria

- Age <=> 18 years
- Willing to participate in all parts of the present study, and willing to confirm this by signing an informed consent.
- Trained in running (performs running exercise <=>1.5 hours/week on average)

Exclusion Criteria

- A history of any hypersensitivity reactions or idiosyncratic reactions in response to paracetamol (acetaminophen) or ibuprofen.
- A history of or ongoing obstructive/inflammatory bowel disease or surgery to the gastro-intestinal tract (not contraindicated: appendectomy or cholecystectomy).
- The presence of an implanted electric (medical) device, such as an ICD or pacemaker.
- Expected to undergo an MRI scan within 5 days after one of the submaximal exercise tests.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>- Core body temperature.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>- Skin Temperature<br /><br>- Interleukin-1*<br /><br>- Interleukin-6<br /><br>- Heart rate<br /><br>- Body Weight<br /><br>- Rating of Perceived Exertion (BORG-score)<br /><br>- Thermal Comfort score<br /><br>- Thermal sensation score</p><br>