Translational Initiative to Map Epigenetics in Sleep

Not yet recruiting

• Conditions: Biological Aging
• Interventions: Other: Surveys

• Registration Number: NCT06333301
• Lead Sponsor: Elysium Health

Brief Summary

The primary aim of TIME-ZZZ is to explore the relationship between chronotype, incidence of depression and biological age, and whether individuals working "out-of-phase" with their chronotype are more likely to exhibit signs of depression and accelerated biological aging.

Detailed Description

Understanding the relationship between chronotype, depression, and biological age is important in the field of sleep research and mental health. Sleep patterns and their alignment with an individual's internal body clock, or chronotype, have been increasingly recognized as influential factors in various aspects of well-being, including mental health and overall physiological aging. By conducting a study that investigates the potential correlation between chronotype, incidence of depression, and biological age, along with the impact of working "out-of-phase" with one's chronotype, the investigators can shed light on crucial aspects of sleep, mental health, and their interplay with biological aging.

Study Timeline

• Status Verified: 2024-03
• Study First Submitted: 2024-03-20
• Study First Submitted QC: 2024-03-26
• Last Update Submitted: 2024-03-26
• Study First Posted: 2024-03-27
• Last Update Posted: 2024-03-27
• Study Start: 2024-04
• Primary Completion: 2034-04
• Study Completion: 2034-04

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: All
• Target Recruitment: 10000

Inclusion Criteria

• Has taken an INDEX test within the last 3 months
• Has registered at least 1 INDEX kit via the Elysium Health website
• Able and willing to provide digital consent to the RSCF, and the TIME-ZZZ Research Subject Consent Form

Exclusion Criteria

• Consent to participate not given

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
TIME-ZZZ	Surveys	Group will complete several surveys

Primary Outcome Measures

Name	Time	Method
Effect of being "out of phase" with chronotype on biological age	At baseline	Determine whether individuals working "out-of-phase" with their chronotype (from TIME-ZZZ survey responses) exhibit higher rates of biological aging compared to those working within their chronotype

Secondary Outcome Measures

Name	Time	Method
Identification of DNA methylation markers associated with chronotype	At baseline	Identify specific DNA methylation markers associated with chronotype (from TIME-ZZZ surveys) thereby providing potential insights into the epigenetic regulation of sleep-wake patterns
Identification of DNA methylation markers associated with depression	At baseline	Identify specific DNA methylation markers associated with depression (from TIME-ZZZ surveys) potentially shedding light on the underlying epigenetic mechanisms involved in the development and progression of depressive disorders.
Effect of Chronotype Alignment and Depression Risk in Relation to Rate of Aging	At baseline	Determine the effect of chronotype alignment and depression risk (from TIME-ZZZ surveys) on biological rate of aging