Systematic Termination of Pharmaceutical Agents Trial (STOPAT): a pilot randomised trial of stopping drug therapy
Not Applicable
Completed
- Conditions
- PolypharmacyPublic Health - Other public health
- Registration Number
- ACTRN12610000865011
- Lead Sponsor
- Royal Perth Hospital
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 40
Inclusion Criteria
i)participant taking at least one drug included in the Target Drug List (antihypertensive therapy, anti-anginal therapy, diuretics, non-steroidal anti-inflammatory drugs and COX-2 inhibitors);
ii) participant has stable chronic disease with respect to the medication targeted for withdrawal
iii)patient reports at least one negative symptom ascribable to the drug therapy (effects specific to drug class, or possible adverse effects such as falls, confusion, malaise and nausea), or the patient is taking more than 5 drugs concurrently
iv) treating physicians concur with randomisation.
Exclusion Criteria
i)patient is taking warfarin
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Proportion of intervention participants in which successful medication withdrawal could be achieved (defined by patient self report)[At conclusion of study. Each participant is assessed at two weekly intervals until i) target medication has been ceased for two weeks; or ii) further dose reductions are not possible (because participant is not clinically stable).]
- Secondary Outcome Measures
Name Time Method