Developing a Multi-scale Account of Attentional Control as the Constraining Interface Between Vision and Action (MAC-Brain).
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 76
- 试验地点
- 1
- 主要终点
- Changes of hemodynamic response in dorsal parietal regions representing specific spatial locations (visual quadrants)
研究概览
简要总结
The project is dedicated to understanding the integration within the brain of signals of different natures that contribute to attentional control. The investigator will make use of standardized experimental displays involving the discrimination of a target (tilted-bar) presented together with 3 distractor items, with one stimulus in each visual quadrant. Across three fMRI experiments in healthy participants, the investigator will manipulate different types of signals that will guide the subject's attention towards one of the four quadrants: Exp 1 - task instruction & item salience; Exp 2 - probabilistic target location; Exp 3 - probabilistic reward. The investigator expects that irrespective of the nature of the control signal, activity in dorsal parietal cortex will index the currently relevant/attended location. Moreover, The investigator expects that upon changes of the most relevant location, one will observe activation of the ventral parietal cortex, plus increased inter-regional connectivity between ventral and dorsal parietal regions - again irrespective of the nature of the attention guiding signals.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 40 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Be 18 to 40 years old
排除标准
- •Previous neurologic or psychiatric disease.
- •Cognitive deficits restricting understanding of the tasks.
- •Pregnant or breath-feeding women.
- •Persons under guardianship, curator or any other administrative or judicial measure of deprivation of rights or liberty.
- •Subjects currently participating in other study.
- •Additional exclusion criteria for a functional magnetic resonance imaging (fMRI) recording:
- •Neurologic, cardiac electrostimulation or defibrillator.
- •Cardiac prostheses
- •Intracranial clips or clamps
- •Cerebrospinal fluid disorders
- •Metal particles in the eyes
- •Metal dental or articular prostheses
- •Diffusion pomp or other infusion system
- •Claustrophobia
- •Head tattoo, make-up, hair gel
- •Have any copper intrauterine device
研究组 & 干预措施
Attentional Control
Visuo-spatial attentional tasks with simple stimuli during functional magnetic resonance imaging (fMRI) scanning.
干预措施: Functional brain imaging without any contrast agent (Other)
结局指标
主要结局
Changes of hemodynamic response in dorsal parietal regions representing specific spatial locations (visual quadrants)
时间窗: Day 0
After spatial pre-processing of individual series of functional magnetic resonance imaging (fMRI) scans, normalization and smoothing as suggested for Statistical Parametric Mapping (SPM) analysis, the different attentional conditions will be modeled and convolved with canonical Hemodynamic Response Function (HRF). The model will be estimated according to the algorithm of SPM. Using a Region of Interest (ROI) approach, the investigator will extract the signal in dorsal parietal regions representing the four visual quadrants, and will compare activity as a function of the attended / most relevant location. The main hypothesis will be confirmed by activation of the ROI corresponding to the currently attended location, irrespective of the nature of the signal guiding attention (i.e. common effects in Exp 1-3).
次要结局
- Evaluation of the connectivity of the ventral parietal cortex at the time when there is a change of the most relevant spatial location/visual quadrant. x²(Day 0)
- Evaluation of the brain hemodynamic response(Day 0)