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临床试验/NCT05466396
NCT05466396招募中不适用

Lung Health of Early Chronic Obstructive Pulmonary Disease: a Multi-center Cohort Study

Ting YANG2 个研究点 分布在 1 个国家目标入组 1,550 人开始时间: 2022年8月1日最近更新:
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适应症

试验速览

阶段
不适用
状态
招募中
发起方
入组人数
1,550
试验地点
2
主要终点
Lung function decline in Pre-COPD and Mild-COPD patients
研究概览研究设计入排标准结局指标研究者研究点记录与标识符相似试验

研究概览

简要总结

This is a multi-center, prospective, cohort study in early COPD patients. This study aims to elucidate the lung function decline and its association with smoking and other risk factors. Other biomarkers and image markers from chest CT scan are also analyzed to investigate the lung function in early COPD patients.

研究设计

研究类型
Observational
观察模型
Cohort
时间视角
Prospective

入排标准

年龄范围
35 Years 至 75 Years（Adult, Older Adult）
性别
All
接受健康志愿者
是

入选标准

  • •Gender: male or female
  • •Age: 35-75 years old
  • •post-bronchodilator spirometry: FEV1/FVC < 0.8 and FEV1%pred ≥80%

排除标准

  • •Other diseases may affect lung function, like lung cancer, bronchiectasis, interstitial lung disease or chest surgery.
  • •BMI > 35 kg/m2
  • •Dementia or other severe neurological disease
  • •Conditions that contraindicated lung function test

结局指标

主要结局

Lung function decline in Pre-COPD and Mild-COPD patients

时间窗: 2 years

FEV1 decline in Pre-COPD and Mild-COPD patients

次要结局

  • Lung function decline in non-smokers with Pre-COPD and Mild-COPD(2 years)
  • Lung function decline in smokers with Pre-COPD and Mild-COPD(2 years)

研究者

发起方
Ting YANG
申办方类型
Other
责任方
Sponsor Investigator
主要研究者

Ting YANG

Vice Director of Respiratory Center

China-Japan Friendship Hospital

研究点 (2)

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