Diagnosis Of Neurological Fetal Anomalies

• Conditions: Fetal Anomaly of Central Nervous System

• Registration Number: NCT05058001
• Lead Sponsor: Sohag University

Brief Summary

This is a descriptive cross-sectional study 300 patients coming for antenatal care at sohag governorate undergo mid anatomical scan.

Samples 300 pregnant women have mid anatomical scan at 20-22 weeks as routine antenatal care and Examination of the fetal CNS will be performed with a high resolution two dimensional ultrasound machine (Voluson E8) equipped with a RAB 4 to 8MHz multifrequency transabdominal Probe. Four standard recommended views-transventricular, falx, cavum, and posterior fossa or transcerebellar views-provide an overview of fetal intracranial anatomy during the second trimester anatomy scan.

Follow-up information will be obtained in all cases, and all infants will be considered healthy by pediatric examination. In selected cases, postnatal single-shot fast spin-echo magnetic resonance (MR) imaging will be performed as integrated, complementary investigation.to confirm diagnosis.

Detailed Description

1. Type of the study: This is a descriptive cross-sectional study

2. Study Setting: 300 patients coming for antenatal care at sohag governorate undergo routine second trimester scan.

3. patients and methods:

Inclusion criteria:

1. All pregnant females of 18 to 45 years old.

2. gestational age of 20- 22 gestational week .

Exclusion criteria:

1-age less than18years and more than 45 years. gestational age less or more than20- 22 weeks. Samples Methods 300 pregnant women low risk pregnancy will be scanned at 20-22 weeks as routine antenatal care and Examination of the fetal CNS will be performed with a high resolution two dimintional ultrasound machine (Voluson E8) equipped with a RAB 4 to 8MHz multifrequency transabdominal Probe. Four standard recommended views-transventricular, falx, cavum, and posterior fossa or transcerebellar views-provide an overview of fetal intracranial anatomy during the second trimester anatomy scan.

Follow-up information will be obtained in all cases, and all infants will be considered healthy by pediatric examination. In selected cases, postnatal single-shot fast spin-echo magnetic resonance (MR) imaging will be performed as integrated, complementary investigation.to confirm diagnosis.

Study Timeline

• Status Verified: 2021-09
• Study First Submitted: 2021-09-10
• Study First Submitted QC: 2021-09-16
• Last Update Submitted: 2021-09-16
• Study First Posted: 2021-09-27
• Last Update Posted: 2021-09-27
• Study Start: 2021-10
• Primary Completion: 2022-04
• Study Completion: 2022-04

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: Female
• Target Recruitment: 300

Inclusion Criteria

• All pregnant females of 18 to 45 years old.
• gestatioal age of 20- 22 gestational week .

Exclusion Criteria

• age less than18years and more than 45 years.
• gestational age less or more than20- 22 weeks.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Accuracy of sonography in the diagnosis of neurological fetal anomalies	From 20 _ 22 gestational age ...confirmation occursat birth till 1 week post natal	Investigator compares the accuracy of songraphy in the diagnosis of neurological fetal anomalies with post natal diagnosis by either clinically or by MRIThis is a descriptive cross-sectional study 2- Study Setting: 300 patients coming for antenatal care at sohag governorate undergo mid anatomical scanExamination of the fetal CNS will be performed with a high resolution two dimintional ultrasound machine (Voluson E8) equipped with a RAB 4 to 8MHz multifrequency transabdominal Probe. Four standard recommended views-transventricular, falx, cavum, and posterior fossa or transcerebellar views-provide an overview of fetal intracranial anatomy during the second trimester anatomy scan.; After birth ,investigator reports anomalies clinically or after consultation of pediatric department.

Trial Locations

Locations (1)

Medicine; 🇪🇬 Sohag, سوهاج, Egypt