A combination of Triamcinolone Acetonide 5 Fluorouracil 5 FU and Verapamil intralesional injection for treatment of Keloid in adults An Interventional Study

1. Keloid still possesses a challenge for clinicians as they are difficult to treat and there is no specific treatment guideline for it.Many treatment modalities are there and various medicine injections have been tried in the treatment of keloid.

2. Verapamil, a calcium channel antagonist, has been recommended in the management of keloids because of its ability to decrease extracellular matrix production and modify fibroblast to increase secretion of procollagenase.

3. Intralesional corticosteroids injection , provide the best relief of local symptoms as well as flattening of the scars themselves due to their anti inflammatory and scar enhancing properties.

4. 5-Fluorouracil(5-FU) selectively inhibits fibroblast proliferation and collagen synthesis.

5. Currently, intralesional corticosteroids is the gold standard non surgical management for keloids.

6. Two medicine combinations of Triamcinolone Acetonide (40 mg/ml) +5 FU (50mg/ml) and Triamcinolone Acetonide (40 mg/ml) +Verapamil (2.5mg/ml) have been tried with good results.

7. The introduction of a triple combination therapy of Triamcinolone Acetonide (40 mg/ml), 5 FU (50mg/ml), and Verapamil (2.5mg/ml) aims to enhance treatment efficacy and expedite the resolution of keloid

8. The lesions and symptoms associated as such impacts the social and interpersonal relation of patients.So it is very important to find solution that will decrease the recurrence and help patient to achieve easy and faster remission.

Update 1:

Number of patients enrolled - 94

Number of patients who completed the study - 10

Number of patients showing loss to follow up - 27

Number of patients showing no result - 1

Adverse Effects - All side-effects were seen locally over keloid

1. Hypopigmentation
2. Telangiectasia
3. Ulceration
4. Vesicle followed by erosion
5. Comedones