Multiple Breath Nitrogen Washout in Healthy Volunteers
- Conditions
- Healthy
- Interventions
- Procedure: Multiple breath nitrogen washout
- Registration Number
- NCT03447418
- Lead Sponsor
- Hospices Civils de Lyon
- Brief Summary
This study is designed to establish reference values of multiple breath nitrogen washout indexes in an healthy population of volunteers (from childhood to adulthood)
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 191
- Informed consent by participant, parent, or legal guardian
- Healthy subjects with a social insurance
- History of a lung chronic disease
- Premature birth (<37th weeks of amenorrhea)
- Acute lower respiratory viral infection within 3 weeks before Multiple Breath washout
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description no treatment, open label Multiple breath nitrogen washout -
- Primary Outcome Measures
Name Time Method Lung Clearance Index 2.5% (LCI 2.5%) Value hour 1 Multiple breath washout is a pulmonary function test that does not require patients' cooperation. It studies the number of lung volumes (turn-over) to clear a gaz such as nitrogen form the lungs. LCI 2,5 is most frequently reported outcome measure. It corresponds to the sum of the total expired lung volumes needed to decrease the initial gaz concretion to its 1/40th, divided by functional residual capacity.
LCI can be measured in infant, preschoolers and thereafter. In order to obtain reproducible tests, three acceptable maneuvers are needed.
- Secondary Outcome Measures
Name Time Method Scond value hour 1 assessment of conductive areas function
Moment ratio M0/M2 Value up to 1 hour Lung Clearance Index 5% (LCI 5%) Value hour 1 Moment ratio M1/M0 Value up to 1 hour Sacin value hour 1 assessment of distal areas function
Trial Locations
- Locations (1)
Hôpital Femme Mère Enfant
🇫🇷Bron, France