Neutrophil Activation in Acute Ischemic Stroke Patients Treated With Endovascular Therapy
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 440
- 试验地点
- 1
- 主要终点
- acute ischemic stroke etiology
研究概览
简要总结
Clinical and experimental data suggest that neutrophil activation and extravasation are deleterious in acute ischemic stroke (AIS) involving an increased risk of unfavorable outcome and hemorrhagic transformation (HT). However, clinical trials targeting neutrophil recruitment in AIS patients were negative. Recently, an experimental study has shown that neutrophil activation and transmigration begin immediately after the occlusion. Inhibition of neutrophil recruitment several hours after the start of ischemia appears therefore too late to have a clinical relevance.
The objective is to study the time dependent impact of neutrophils in AIS and the predominant mediators in each time point to identify the appropriate therapeutic target and time window.
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •age >= 18 years old
- •acute ischemic stroke secondary to a large vessel occlusion.
- •Patients hospitalized for endovascular therapy.
排除标准
- •Pregnant or breast feeding patient
- •patient under legal protection
- •Patient opposition to participate in this study
结局指标
主要结局
acute ischemic stroke etiology
时间窗: within 24 hours after endovascular procedure
as defined by the Trial of Danaparoid (ORG10172) in Acute Stroke Treatment (TOAST classification)
mortality
时间窗: 3 months
severity of neurologic symptoms
时间窗: baseline
National Institutes of Health Stroke Scale (NIHSS)
neutrophil protease counts
时间窗: 24 hours after recanalization
neutrophil counts
时间窗: 24 hours after recanalization
Plasma neutrophil activation bio-markers
disruption of the blood-brain-barrier
时间窗: within 24 hours after endovascular procedure
diagnosis on cerebral Computerized Tomography
Recovery of motor function after stroke
时间窗: 3 months
modified Rankin scale
recanalization score
时间窗: immediately after endovascular procedure
Thrombolysis in Cerebral Infarction classification (TICI)
brain haemorrhage
时间窗: 24 hours after endovascular procedure
National Institutes of Health Stroke Scale (NIHSS)
free plasma DNA counts
时间窗: 24 hours after recanalization
adhesion molecules counts
时间窗: 24 hours after recanalization
adhesion molecules counts
时间窗: immediately after recanalization
free plasma DNA counts
时间窗: before recanalization
free plasma DNA counts
时间窗: immediately after recanalization
neutrophil counts
时间窗: before recanalization
Plasma neutrophil activation bio-markers
neutrophil counts
时间窗: immediately after recanalization
Plasma neutrophil activation bio-markers
neutrophil protease counts
时间窗: before recanalization
adhesion molecules counts
时间窗: before recanalization
neutrophil protease counts
时间窗: immediately after recanalization
次要结局
未报告次要终点