Heparin Dose for Radial Angiography

Phase 4

Completed

• Conditions: Coronary Angiograph
• Interventions: Drug: unfractionated heparin

• Registration Number: NCT01634438
• Lead Sponsor: University of Alberta

Brief Summary

At present, coronary angiogram is usually performed either through an artery in your groin or wrist. An important limitation of the wrist approach is an increase rate of blockage of the wrist artery. It is possible that the dose of blood thinner (i.e. heparin) may decrease the risk of blockage. Early studies seem to suggest that higher dose is required to reduce the risk of this important complication. However, to date there has not been a definitive study to determine the most appropriate heparin dose for the prevention of this complication. The main goal of this study is to determine the appropriate heparin dose to prevent wrist artery blockage and to determine risk factors for developing such a complication.

Detailed Description

Not available

Study Timeline

• Study Start: 2008-07
• Primary Completion: 2010-12
• Study Completion: 2010-12
• Study First Submitted: 2012-06-28
• Status Verified: 2012-07
• Study First Submitted QC: 2012-07-02
• Last Update Submitted: 2012-07-02
• Study First Posted: 2012-07-06
• Last Update Posted: 2012-07-06

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 49

Inclusion Criteria

• Patients older than 18 years of age who were referred for either urgent or elective cardiac catheterization were eligible for the study if a normal Allen's test was demonstrated

Exclusion Criteria

• myocardial infarction with shock,
• ST-elevation myocardial infarction,
• patients undergoing planned percutaneous coronary intervention, and
• patients in whom transradial approach is contraindicated such as hemodialysis patients

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
low dose heparin	unfractionated heparin	30 units per kilogram of unfractionated heparin
High dose heparin	unfractionated heparin	70 units per kilogram of unfractionated heparin (UFH) intravenously

Primary Outcome Measures

Name	Time	Method
radial artery occlusion	one month	The primary endpoint was radial artery occlusion defined as absence palpable radial artery with no flow as assessed by Doppler study

Trial Locations

Locations (1)

Mazankowski Alberta Heart Institute; 🇨🇦 Edmonton, Alberta, Canada