Low Versus High Dose Unfractionated Heparin in Patients Undergoing Angiography Via the Radial Artery
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 入组人数
- 49
- 试验地点
- 1
- 主要终点
- radial artery occlusion
研究概览
简要总结
At present, coronary angiogram is usually performed either through an artery in your groin or wrist. An important limitation of the wrist approach is an increase rate of blockage of the wrist artery. It is possible that the dose of blood thinner (i.e. heparin) may decrease the risk of blockage. Early studies seem to suggest that higher dose is required to reduce the risk of this important complication. However, to date there has not been a definitive study to determine the most appropriate heparin dose for the prevention of this complication. The main goal of this study is to determine the appropriate heparin dose to prevent wrist artery blockage and to determine risk factors for developing such a complication.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients older than 18 years of age who were referred for either urgent or elective cardiac catheterization were eligible for the study if a normal Allen's test was demonstrated
排除标准
- •myocardial infarction with shock,
- •ST-elevation myocardial infarction,
- •patients undergoing planned percutaneous coronary intervention, and
- •patients in whom transradial approach is contraindicated such as hemodialysis patients
研究组 & 干预措施
low dose heparin
30 units per kilogram of unfractionated heparin
干预措施: unfractionated heparin (Drug)
High dose heparin
70 units per kilogram of unfractionated heparin (UFH) intravenously
干预措施: unfractionated heparin (Drug)
结局指标
主要结局
radial artery occlusion
时间窗: one month
The primary endpoint was radial artery occlusion defined as absence palpable radial artery with no flow as assessed by Doppler study
次要结局
未报告次要终点
研究者
Robert Welsh
Principal Investigator
University of Alberta