Assessment of the Effects of Prone Positioning Among ARDS Patients on Ventilation Homogenization by the Phase Iii Slope of the Volumetric Capnography
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- Change from baseline in phase iii slope of the volumetric capnograph
研究概览
简要总结
This study evaluates the effects of prone positioning on homogenization of ventilation.
详细描述
After initiation of mechanical ventilation and assessing the eligibility of the patient, informed consent will be taken from the closest kin. If eligible, following steps will be performed which are part of standard ARDS patient care.
- Low-flow Pressure Volume curve and assessment of airway opening pressure
- Calculation of recruitment to inflation ratio
- Optimizing Positive End-Expiratory Pressure
Afterwards, phase III slope of the patient will be recorded at four timepoints:
Supine 1 (immediately before turning to prone position) Prone 1 (immediately after prone position) Prone 2 (at the end of the 16-24 hour prone cycle) Supine 2 (immediately after turning to supine position)
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •ARDS criteria met
- •intubated and mechanically ventilated as a result of respiratory failure
- •PaO2/FiO2 <200
排除标准
- •age older than 18
- •Chronic pulmonary disease, pneumothoraces, intraabdominal hypertension (> 12 mmHg), pregnancy, not expected to survive >24 hours, hemodynamic instability
结局指标
主要结局
Change from baseline in phase iii slope of the volumetric capnograph
时间窗: 16 to 24 hours (according to time spent in the prone position)
phase iii slope is associated with the ventilation homogeneity
correlation of the phase iii slope with the recruitment to inflation ratio
时间窗: 16 to 24 hours (according to time spent in the prone position)
recruitment to inflation ratio is a simple bedside tool that indicates a higher possible recruitable lung with higher applied Positive End-Expiratory Pressure
次要结局
- correlation of the phase iii slope with the Partial pressure of the arterial oxygen/ Fraction of inspired O2 concentration (PaO2/FiO2) ratio(16 to 24 hours (according to time spent in the prone position))
研究者
Olcay Dilken
MD
Istanbul University - Cerrahpasa (IUC)