An Open-lable Investigation of the Effect of rTMS on Attention in an Adult Sample Suffering From ADD
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 10
- 试验地点
- 2
- 主要终点
- Change in performance
研究概览
简要总结
The purpose of the current open-lable study was to use low-frequency repetitive transcranial magnetic stimulation (rTMS) to improve the attention deficits in a sample of adult patients suffering from attention deficit disorder. Participants received 10 sessions of rTMS over Fz (located using the EEG 10-20 international system) and underwent assessments of their attentional capacity using the gradCPT task in an fMRI scanner, before and after the intervention. Other behavioral assessments of their attention symptoms have also been conducted.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Normal intelligence level (>90)
- •Diagnosis of ADD by a psychiatrist using the ADHD-RS-IV with Adult Prompts
排除标准
- •Scores of 21 or more on BDI and/or BAI
- •History of head trauma
- •History of a major psychological or neurological condition
- •Presence of metal in the head
- •History of seizures
- •Serious cardiovascular disease
- •Use of medications with an impact on cognitive functions during the treatment window (patients with a constant and stable dose were included)
- •Recent use of alcohol or substance abuse
结局指标
主要结局
Change in performance
时间窗: Up to 10 days, i.e., before and after the completion of the 10 sessions of rTMS
Shortened version (4 min) of the continuous go/no-go task: gradual-onset continuous performance task (gradCPT)
次要结局
- Change in self-report attention scores(Baseline, after 5 days of stimulation, after 10 days of stimulation; Range= 0-6; Higher scores represent worse outcome)
- Change in investigator-rated attention scores(Baseline, after 5 days of stimulation, after 10 days of stimulation; Range:0 - 54; Higher scores represent worse outcome)
研究者
reza kazemi
Assistant professor
University of Tehran