Efficacy of Repetitive Transcranial Magnetic Stimulation in Adult Attention Deficit Disorder

Not Applicable

Completed

• Conditions: ADHD; Attention Deficit Disorder
• Interventions: Device: repetitive Transcranial Magnetic Stimulation

• Registration Number: NCT06030024
• Lead Sponsor: University of Tehran

Brief Summary

The purpose of the current open-lable study was to use low-frequency repetitive transcranial magnetic stimulation (rTMS) to improve the attention deficits in a sample of adult patients suffering from attention deficit disorder. Participants received 10 sessions of rTMS over Fz (located using the EEG 10-20 international system) and underwent assessments of their attentional capacity using the gradCPT task in an fMRI scanner, before and after the intervention. Other behavioral assessments of their attention symptoms have also been conducted.

Detailed Description

Not available

Study Timeline

• Study Start: 2021-09-01
• Primary Completion: 2023-02-01
• Study Completion: 2023-03-01
• Status Verified: 2023-09
• Study First Submitted: 2023-09-01
• Study First Submitted QC: 2023-09-01
• Study First Posted: 2023-09-08
• Last Update Submitted: 2023-09-12
• Last Update Posted: 2023-09-14

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 10

Inclusion Criteria

• Normal intelligence level (>90)
• Diagnosis of ADD by a psychiatrist using the ADHD-RS-IV with Adult Prompts

Exclusion Criteria

• Scores of 21 or more on BDI and/or BAI
• History of head trauma
• History of a major psychological or neurological condition
• Presence of metal in the head
• History of seizures
• Serious cardiovascular disease
• Use of medications with an impact on cognitive functions during the treatment window (patients with a constant and stable dose were included)
• Recent use of alcohol or substance abuse

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Active rTMS	repetitive Transcranial Magnetic Stimulation	Participants in this one and only arm in the current study received active repetitive transcranial magnetic stimulation.

Primary Outcome Measures

Name	Time	Method
Change in performance	Up to 10 days, i.e., before and after the completion of the 10 sessions of rTMS	Shortened version (4 min) of the continuous go/no-go task: gradual-onset continuous performance task (gradCPT)

Secondary Outcome Measures

Name	Time	Method
Change in self-report attention scores	Baseline, after 5 days of stimulation, after 10 days of stimulation; Range= 0-6; Higher scores represent worse outcome	The 6-item ASRS-V1.1 Adult ADHD Self-Report
Change in investigator-rated attention scores	Baseline, after 5 days of stimulation, after 10 days of stimulation; Range:0 - 54; Higher scores represent worse outcome	Investigator-Rated Attention-Deficit Hyperactivity Disorder (ADHD) Rating Scale-IV (I-ADHD RS-IV) with adult prompts

Trial Locations

Locations (1)

National Brain Mapping Lab; 🇮🇷 Tehran, Iran, Islamic Republic of