Acquisition and Retention of Motor Memories in Adults and Typically Developing Children

Not Applicable

• Conditions: Memory
• Interventions: Other: Functionel MRI

• Registration Number: NCT04598945
• Lead Sponsor: University Hospital, Grenoble

Brief Summary

Our motor skills require motor memories without which our behavior is only reflexes and stereotypies. The way which these memories form in the human brain constitute therefore a major challenge for neuroscience research. Some a lot of evidence suggests that any new motor skills is acquired in the cerebellum and then persisted in the cortex. This vision seems however caricature, the formation of memories motor probably requiring complex remodeling of cortico-cerebellar networks. The MotorMemo project aspires to better understand this remodeling, by testing more specifically the hypothesis of cerebellar weakening and strengthening cortical as a substrate for the formation of motor memories. A longitudinal study using a sensorimotor adaptation protocol, fMRI as well as a developmental perspective is proposed to verify this hypothesis.

Detailed Description

A fundamental human faculty is that of adapting our motor behavior to changing environmental conditions. This faculty is comparable to an apprenticeship adaptive during which the individual updates, on a trial and error basis, the correspondence between sensory inputs and the resulting motor commands. Once updated, these correspondences or internal models allow the individual to produce a behavior precise and reproducible motor. The issue of model acquisition and retention internal movement is therefore central to our understanding of motor control. Relatedly, this question constitutes a gateway to a more comprehensive understanding of the mechanisms of learning and procedural memory.

The MotorMemo project therefore aims to study the formation of internal models of movement in the human brain, with the particularity of being interested in the correlates cerebral processes of acquiring and retaining an internal model of visuomotor transformation in healthy children (8-12 years) and adults.

Study Timeline

• Study First Submitted: 2020-10-16
• Study First Submitted QC: 2020-10-16
• Study Start: 2020-10-20
• Study First Posted: 2020-10-22
• Status Verified: 2020-11
• Last Update Submitted: 2020-11-16
• Last Update Posted: 2020-11-17
• Primary Completion: 2022-10-01
• Study Completion: 2022-11-01

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

• right-handed
• affiliated to a social security scheme
• who gave their consent to participate in the study

Exclusion Criteria

• Contraindication to MRI

• visual impairment;

• suffering from one of the following pathologies:

  • dysphasia,
  • ADHD,
  • dyspraxia,
  • dyslexia,
  • dysorthography,
  • dyscalculia;
  • history of epilepsy

• subject in period of exclusion from another study,

• subject under administrative or judicial supervision

• pregnant or breastfeeding women

• Persons referred to in articles l1121-8

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Adults	Functionel MRI	The subject will be subjected to 2 functional MRI sessions spaced 3 days apart Each session will be composed of the same MRI sequences without injection, namely an anatomical exploration sequence followed by sequences of functional exploration of rest and activation (while the subject performs the task motor). The resting functional exploration sequences will frame (1 before, 1 after) the functional activation sequence.
Children	Functionel MRI	The subject will be subjected to 2 functional MRI sessions spaced 3 days apart Each session will be composed of the same MRI sequences without injection, namely an anatomical exploration sequence followed by sequences of functional exploration of rest and activation (while the subject performs the task motor). The resting functional exploration sequences will frame (1 before, 1 after) the functional activation sequence.

Primary Outcome Measures

Name	Time	Method
Evaluate, in adults and children, whether the acquisition and retention of a new internal movement pattern are linked to the activation of a large cortico-cerebellar network ladder.	3 days	Change in cerebellar activation and cortical induced by the visuomotor adaptation task compared to a task motor control not requiring adaptation

Trial Locations

Locations (1)

CHU Grenoble-Alpes; 🇫🇷 Grenoble, France