Primary Tumour Response to Induction Chemotherapy in Synchronously Metastasized Colorectal Cancer
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- Pathological response of the primary tumour
研究概览
简要总结
We performed a retrospective data analysis of patients with synchronously metastasized colorectal cancer, comparing the histological response on the primary tumour to chemotherapy combined with either vascular endothelial growth factor (VEGF) or epidermal growth factor receptor (EGFR) inhibition.
详细描述
We performed a retrospective analysis regarding the response of the primary tumour and the liver metastases of patients with colorectal carcinoma to an induction chemotherapy with antibody therapy, either with a VEGF antibody, or with an EGFR antibody.
We investigated 100 Patients with synchronous metastatic colorectal carcinoma, who underwent hepatic resection in Clinic Landstraße or Clinic Favoriten between 2014 and 2021.
We investigated the tumour response of the primary tumour, using Rödel score, which is a tumour regression score.
We also investigated the tumour response of the liver metastases using Rubbia Brandt tumour regression score.
The pathological response was assessed postoperatively in the surgical specimen. In order to ensure a uniform assessment, the pathologists in our HPB center assessed the histological specimens from both treatment locations prior to this analyses.
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •older than 18 years
- •synchronously hepatic metastasized patients with colorectal carcinoma
- •indication of surgical treatment
排除标准
- •younger than 18 years
- •metachronously metastasized patients
结局指标
主要结局
Pathological response of the primary tumour
时间窗: Tumour regression was assessed in the surgical specimen 3 to 7 days after surgery.
Investigation of the tumour response of the primary tumor (colorectal carcinoma) using the Rödel Score (tumour regression score)
次要结局
- Pathological response of the liver metastases(Tumour regression was assessed in the surgical specimen 3 to 7 days after surgery. Radiological response was assessed in staging CT abdomen 2 to 4 weeks after induction chemotherapy.)
- Overall survival(median of 21 months (0 to 80))
- Recurrece free survival(median of 21 months (0-80))
- 90 day mortality(90 days)
研究者
Thomas Gruenberger
Prim. Prof. Dr. med.
Klinik Favoriten