A Study On Efficacy Of Microneedling With Topical Metformin Versus Microneedling With Topical Glutathione In Treatment Of Melasma A Randomized Controlled Study
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 60
- 试验地点
- 1
研究概览
简要总结
This randomized parallel group clinical trial will evaluate the efficacy and safety of microneedling with topical metformin compared to microneedling with topical glutathione in adult female patients with facial melasma. Sixty participants will be allocated into two equal groups and receive eight monthly treatment sessions. Clinical improvement will be assessed using modified Melasma Area And Severity Index scores and a global photographic assessment scale, along with documentation of adverse effects and patient satisfaction. The study aims to identify which microneedling assisted topical therapy provides greater pigmentation reduction and better tolerability, thereby offering an effective and affordable option for melasma management.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 盲法
- None
入排标准
- 年龄范围
- 20.00 Year(s) 至 50.00 Year(s)（—）
- 性别
- Female
入选标准
- •Female patients aged twenty to fifty years with clinically diagnosed facial melasma Fitzpatrick skin type three or four willing to give informed consent and comply with study protocol and not receiving any melasma treatment for at least three months prior to enrollment.
排除标准
- •Patients who are pregnant or breastfeeding Females with PCOD Smokers Active hormonal therapy Consumption of antioxidants in last Three months Use of isotretinoin in past six months Active inflammatory acne lesions Drugs causing photosensitivity and hyperpigmentation as epileptic drugs Antimilaria and tetracycline.
研究者
Dr Yashaswini G S
Sri Devaraj Urs Medical College