Fructooligosaccharide and Calcium Absorption in Adolescent Girls
Trial Snapshot
- Phase
- Phase 1
- Status
- Completed
- Sponsor
- Purdue University
- Enrollment
- 26
- Locations
- 2
- Primary Endpoint
- Fractional Calcium Absorption
Study Overview
Brief Summary
Fructooligosaccharides (FOS) are believed to have positive effects on calcium absorption and bone accrual during growth. This study aims to see whether the addition of fiber in the form of FOS to a calcium-containing beverage will increase calcium absorption. During two clinical visits, participants will receive a beverage containing a small amount of calcium, supplemented with either no dietary fiber or a small amount of fiber. Height, weight, bone density and geometry, calcium absorption, and physical fitness will be measured. The effects of this fiber intervention may provide support for improving bone health with minimal fiber supplementation.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Crossover
- Primary Purpose
- Prevention
- Masking
- Single (Participant)
Eligibility Criteria
- Ages
- 10 Years to 12 Years (Child)
- Sex
- Female
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •Calcium intake of 900-1300 mg/d
- •Generally healthy
Exclusion Criteria
- •BMI > 90th percentile for age
- •Takes medication that influences calcium metabolism
- •Any disorder of calcium or bone homeostasis (hypercalcemia, Paget's Disease)
- •Smoking, illegal drug consumption
- •Any gastrointestinal disease (Crohn's Disease, Celiac Disease, Inflammatory Bowel Disease)
Outcomes
Primary Outcomes
Fractional Calcium Absorption
Time Frame: 24 h urine and 3 h blood
Secondary Outcomes
- Bone density and geometry measured with peripheral quantitative computed tomography (pQCT)(Initial visit)
Investigators
Berdine Martin
Research Scientist, Nutrition Science
Purdue University