Fructooligosaccharide and Calcium Absorption in Adolescent Girls
试验速览
- 阶段
- 1 期
- 状态
- 已完成
- 入组人数
- 26
- 试验地点
- 2
- 主要终点
- Fractional Calcium Absorption
研究概览
简要总结
Fructooligosaccharides (FOS) are believed to have positive effects on calcium absorption and bone accrual during growth. This study aims to see whether the addition of fiber in the form of FOS to a calcium-containing beverage will increase calcium absorption. During two clinical visits, participants will receive a beverage containing a small amount of calcium, supplemented with either no dietary fiber or a small amount of fiber. Height, weight, bone density and geometry, calcium absorption, and physical fitness will be measured. The effects of this fiber intervention may provide support for improving bone health with minimal fiber supplementation.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Prevention
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 10 Years 至 12 Years（Child）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Calcium intake of 900-1300 mg/d
- •Generally healthy
排除标准
- •BMI > 90th percentile for age
- •Takes medication that influences calcium metabolism
- •Any disorder of calcium or bone homeostasis (hypercalcemia, Paget's Disease)
- •Smoking, illegal drug consumption
- •Any gastrointestinal disease (Crohn's Disease, Celiac Disease, Inflammatory Bowel Disease)
结局指标
主要结局
Fractional Calcium Absorption
时间窗: 24 h urine and 3 h blood
次要结局
- Bone density and geometry measured with peripheral quantitative computed tomography (pQCT)(Initial visit)
研究者
Berdine Martin
Research Scientist, Nutrition Science
Purdue University