Early Amniotic Membrane Transplantation in Bacterial Keratitis

Not Applicable

• Conditions: Keratitis of Both Eyes

• Registration Number: NCT02716883
• Lead Sponsor: Farabi Eye Hospital

Brief Summary

In this study Investigators are going to do early amniotic membrane transplantation (AMT) for bacterial keratitis.

Detailed Description

In this study investigators are going to do amniotic membrane transplantation (AMT), early in the first week for bacterial keratitis. Investigators are comparing this technique with no amniotic membrane transplantation (NAMT) in a clinical trial, Inform consent is going to be taken, then the enrolment population is added in the study. Investigators are going to compare the final scar size, the time to scar formation, perforation rate , early need to penetrating keratoplasty (PKP), risk of vision loss (being no light perception (NLP) between two groups.This trial has been approved by the review board in Tehran University of Medical Sciences.( 487/5671)

Study Timeline

• Study Start: 2014-01
• Study First Submitted: 2015-08-13
• Status Verified: 2016-03
• Study First Submitted QC: 2016-03-17
• Study First Posted: 2016-03-23
• Last Update Submitted: 2016-03-26
• Last Update Posted: 2016-03-29
• Primary Completion: 2016-04
• Study Completion: 2016-04

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 14

Inclusion Criteria

Bacterial keratitis being in the first week of diagnosis medically undergoing treatment

Exclusion Criteria

thinning limbal extension intraocular extension underlying disease Nocardia keratitis

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
Time to scar formation	It needs at most 3 months	The time keratitis needs for scar to be formed