The Effects Of Injectable Platelet-Rich Fibrin Application On Wound Healing Following Gingivectomy and Gingivoplasty Operations: Single-blind, Randomized Controlled, Prospective Clinical Study
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Wound Heal
- Sponsor
- Saglik Bilimleri Universitesi
- Enrollment
- 46
- Locations
- 1
- Primary Endpoint
- effects of I-PRF on wound healing and epithelialization
- Status
- Completed
- Last Updated
- 2 years ago
Overview
Brief Summary
The study aims to evaluate the effects of injectable platelet-rich fibrin (I-PRF) applications on early wound healing after gingivectomy and gingivoplasty surgery. In this randomized controlled single-blind study, gingivectomy and gingivoplasty surgeries were performed on 46 patients. The postoperative I-PRF-applied surgery areas were compared with control regions. The surgical areas were stained with Mira-2 tone and evaluated in the ImageJ program. Wound healing was evaluated by using the Modified Manchester Scar (MMS) scale and Landry, Turnbull, and Howley (LTH) index. Vascular endothelial growth factor (VEGF) and fibroblast growth factor 10 (FGF-10) concentrations were assessed by enzyme-linked immunoabsorbent assay (ELISA). The seven-day Visual Analog Scale was used to assess pain level.
Considering the results found, I-PRF applications revealed positive effects on epithelial wound healing after gingivectomy and gingivoplasty operations.
Investigators
Şeyma Çardakçı
Lecturer
Saglik Bilimleri Universitesi
Eligibility Criteria
Inclusion Criteria
- •(a) systemically healthy patients ages 15-40 years, (b) pregnancy or lactation, (c) patients with chronic inflammatory gingival overgrowth in the mandibular and maxillary anterior area, (d) no attachment and bone loss, (e) not using immunosuppressive agents, systemic corticosteroids, chemotherapy, and/or radiotherapy drugs taken or prescribed 2 months before the study attempt, which may affect the study results, wound healing, and coagulation mechanism, and (f) patients with sufficient oral hygiene.
Exclusion Criteria
- •(a) patients who had a history of periodontal treatment in the last 6 months, (b) smokers and alcohol users, those who used drugs that may cause gingival enlargement in the last 6 months, (c) patients with poor communication, and (d) patients who did not attend controls at designated times.
Outcomes
Primary Outcomes
effects of I-PRF on wound healing and epithelialization
Time Frame: seven months
I-PRF applications revealed positive effects on epithelial wound healing after gingivectomy and gingivoplasty operations.
Secondary Outcomes
- effects of biochemical markers on wound healing(seven months)