Evaluating the effects of exercises in patients with thalassemia major

Not Applicable

Conditions: Thalassemia major disease.
Beta thalassaemia
D56.1

Registration Number: IRCT20230515058202N1

Lead Sponsor: Bandare-abbas University of Medical Sciences

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Complete

Sex: All

Target Recruitment: 50

Inclusion Criteria

Thalassemia major patients who undergo regular blood transfusions and receive packed cells every month.
Patients receiving iron chelator with regular blood transfusion such as desferal or deferiprone at the same time.
Left ventricular ejection fraction equal to or more than 50%
New York Heart Association (NYHA) functional class I, II, or III.
Being in the age range of 18 to 40 years
Having the desire and motivation to participate in the training program

Exclusion Criteria

Severe exercise intolerance
uncontrolled arrhythmia,
uncontrolled angina pectoris,
severe kidney or lung disease,
musculoskeletal or neuromuscular conditions that preclude exercise or exercise testing, and signs or symptoms of ischemia and abnormal hemodynamic responses during previous incremental exercise test,
suffering from severe mental and psychiatric diseases,
use of psychoactive drugs,
uncontrolled blood pressure and diabetes,
clinical evidence of other secondary causes of pulmonary hypertension including HIV infection, hepatitis virus infection, Collagen vascular diseases, cirrhosis, chronic obstructive airway diseases and acquired heart disease associated with pulmonary hypertension.

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Ferritin. Timepoint: Before the intervention and after the intervention. Method of measurement: Serum ferritin level by chemiluminescence method with Abbott Architect i1000SR Immunoassay System.

Secondary Outcome Measures

Name	Time	Method
Quality of Life. Timepoint: Before the intervention and after the intervention. Method of measurement: SF-36 questionnaire.;Mental health. Timepoint: Before the intervention and after the intervention. Method of measurement: SCL-90-R questionnaire.;HR Recovery. Timepoint: Before the intervention and after the intervention. Method of measurement: exercise test.;Exercise capacity. Timepoint: Before the intervention and after the intervention. Method of measurement: 6-minute walk test.;Cardiac function. Timepoint: Before the intervention and after the intervention. Method of measurement: Echocardiography.