The Association Between Venous Excess Ultrasound, the Lung Ultrasound Score and Acute Kidney Injury and Death in the Intensive Care Unit Population
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 136
- 试验地点
- 1
- 主要终点
- Rate of acute kidney injury
研究概览
简要总结
Fluid resuscitation is one of the cornerstones of treatment in ICU patients. Nonetheless, excessive fluid administration can lead to fluid overload which has been associated with worse outcomes in the ICU. To prevent this, assessments of fluid responsiveness are commonly employed. However, fluid responsiveness does not take fluid tolerance into account. Fluid tolerance is the idea that a patient might still be fluid responsive but might already be at risk of the detrimental effects of fluid therapy. Recent developments in point of care ultrasound e.g. the Venous excess ultrasound might help identify patients at risk of fluid overload. However its association with patient relevant outcomes in the ICU remains unclear.
详细描述
This study will investigate the association between the venous excess ultrasound grading system (VExUS) and patient relevant outcomes such as acute kidney injury, mortality and length of stay.
A secondary analysis is planned where the association between VExUS and the lung ultrasound score will be investigated
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •all patients admitted to the ICU 18 years or older expected to stay in the ICU for more than 24 hours
排除标准
- •any obstruction between the righ atrium and structures assessed by VExUS
- •a medical history of: Major cardiac shunts (e.g. atrial septum defect), Tricuspid regurgitation, dialysis, portal hypertension, pulmonary hypertension, interstitial lung disease, recipients of a kidney of liver transplant.
- •patients in whom an ultrasound assesment is unfeasible e.g. a BMI over 40
结局指标
主要结局
Rate of acute kidney injury
时间窗: within 30 days of admission to the ICU
Clinically relevant acute kidney injury in the ICU: a 200% rise in creatinine or the use of renal replacement therapy
Mortality
时间窗: within 30 days of admission to the ICU
death of all causes
Rate of MAKE-30
时间窗: within 30 days of admission to the ICU
a composite endpoint of mortality and acute kidney injury ( including renal replacement therapy)
次要结局
未报告次要终点
研究者
P.R. Tuinman
Dr. P.R. Tuinman, Principal Investigator
Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)