Effects of acute postoperative pain management on the body's stress response
Not Applicable
- Conditions
- Postoperative pain after lumbotomy incision
- Registration Number
- SLCTR/2012/005
- Lead Sponsor
- The Ministry of Science, Education, and Sports of the Republic of Croatia
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- Not specified
Inclusion Criteria
Adult patients (aged more than 18 years) ASA I and II undergoing open kidney surgery with lumbotomy (nephrectomy, nephrolithotomy, pyeloplastic surgery, kidney resection, adrenalectomy).
Exclusion Criteria
Patients with ASA III and IV, diabetes mellitus, advanced cancer, psychiatric disorders, cognitive deficits, and taking immunosupressive therapy
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Differences between three groups in the levels of metabolic markers (leukocyte count, lymphocyte count, CRP, fibrinogen, and blood glucose), stress hormones (prolactin, cortisol, adrenalin), and cytokines (interleukin IL-1, IL-6, IL-1RA). [Preoperatively and 4, 24, and 48 hours after induction of analgesia.]<br>
- Secondary Outcome Measures
Name Time Method Decrease in the visual analogue scale (VAS) score; changes in clinical status (ECG, SaO2, BP, HR), and occurence of complications (atelectasis, pneumonia). [Every 4 hours in the first 48 hours postoperatively.]<br>