NCT00681525已完成1 期
A Multiple-Dose Pharmacokinetic Interaction Study Between ABT-335, Atorvastatin and Ezetimibe
适应症
干预措施
相关药物
试验速览
- 阶段
- 1 期
- 状态
- 已完成
- 发起方
- Abbott
- 入组人数
- 18
- 试验地点
- 1
- 主要终点
- PK interaction
研究概览
简要总结
The objective of this study is to evaluate the potential PK interaction between ABT-335, atorvastatin 80 mg and ezetimibe 10 mg when administered concurrently.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 55 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Healthy male or female subjects
排除标准
- •Clinically significant diseases or disorders
- •Positive screens for drug and alcohol
- •Pregnant or breast-feeding females
- •Any history of surgery(ies) that might interfere with the gastrointestinal motility, pH or absorption
研究组 & 干预措施
A
Experimental
ABT-335 135 mg
干预措施: ABT-335 (Drug)
B
Experimental
Atorvastatin 80 mg and Ezetimibe 10 mg
干预措施: Atorvastatin (Drug)
B
Experimental
Atorvastatin 80 mg and Ezetimibe 10 mg
干预措施: Ezetimibe (Drug)
C
Experimental
ABT-335 135 mg, Atorvastatin 80 mg and Ezetimibe 10 mg
干预措施: ABT-335 (Drug)
C
Experimental
ABT-335 135 mg, Atorvastatin 80 mg and Ezetimibe 10 mg
干预措施: Atorvastatin (Drug)
C
Experimental
ABT-335 135 mg, Atorvastatin 80 mg and Ezetimibe 10 mg
干预措施: Ezetimibe (Drug)
结局指标
主要结局
PK interaction
时间窗: Study duration approximately 62 days
次要结局
未报告次要终点
研究者
研究点 (1)
Loading locations...
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