To assess the therapeutic efficacy of Seer (Allium sativum) in Atherosclerosis in patients of Type 2 Diabetes Mellitus

Not Applicable

Conditions: Health Condition 1: I709- Other and unspecified atherosclerosis

Registration Number: CTRI/2022/12/047805

Lead Sponsor: Department of Moalejat Faculty of Unani Medicine AKTC Aligarh Muslim University

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: ot Yet Recruiting

Sex: Not specified

Target Recruitment: 0

Inclusion Criteria

Patients in age group of 30-65 years.

Patients of either sex.

Controlled case of Type 2 Diabetes Mellitus either by drug or life style modification.

Fasting blood sugar <= 140 mg/dl or HbA1c- <= 7%

Patients able to participate in the study to follow the instructions

Subjective Parameters:

Patients showing any one of the following symptoms will be suspected and has to go further screening through Diabetes Risk Profiler and Investigations;

1.Increasing body weight

2.Fatigue

3.Exertional dyspnea

4.Xanthelasma

5.Corneal arcus

6.Controlled Essential Hypertension

Objective Parameters:

1.Arterial stiffness index to be evaluated with Diabetes Risk Profiler (Borderline,

Mild & Moderate Arterial stiffness)

2.Fasting blood sugar <= 140 mg/dl or HbA1c- <= 7%

3.Lipid profile:

Any two of the following

1.Total Cholesterol: 200-300 mg/dl

2.Serum Triglyceride: 200-300 mg/dl

3.LDL Cholesterol: 100-150 mg/dl

4.HDL Cholesterol: 30-50 mg/dl

5.VLDL Cholesterol: 30-50 mg/dl

Exclusion Criteria

Exclusion Criteria:

1.Patients below 30 years and above 65 years of age.

2.Uncontrolled case of Type 2 Diabetes Mellitus. HbA1c > 7%

3.Arterial Stiffness Index (Severe Arterial Stiffness)

4.Patients on lipid-lowering drugs

5.Any co-morbid condition

6.Alcoholic

7.Pregnant and lactating women.

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Improvement in Arterial Stiffness Index <br/ ><br>Arbitrary Scale for improvement in Arterial Stiffness <br/ ><br>Grade 0 No arterial stiffness Complete improvement <br/ ><br>Grade 1 Borderline arterial stiffness Partial improvement <br/ ><br>Grade 2 Mild arterial stiffness Slight improvement <br/ ><br>Grade 3 Moderate arterial stiffness No improvementTimepoint: Assessment of arterial stiffness through DRP at the initiation of treatment <br/ ><br>0 day and at the end of the study 90th day <br/ ><br>

Secondary Outcome Measures