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临床试验/ITMCTR2200005709
ITMCTR2200005709招募中未知

Efficacy and Safety of Tripterygium Wilfordii Multiglycosides in Idiopathic Membranous Nephropathy: Protocol for An Open-label Randomized Controlled Clinical Trial

Department of Nephrology, Sichuan Provincial People's Hospital0 个研究点开始时间: 待定最近更新:

试验速览

阶段
未知
状态
招募中
发起方

研究概览

简要总结

暂无简介。

研究设计

研究类型
Interventional study

入排标准

年龄范围
18 至 65(—)
性别
All

入选标准

  • 1.Idiopathic membranous nephropathy was confirmed by renal biopsy pathology or high titer anti-PLA2R antibody;
  • 2.Aged 18 to 65 years;
  • 3.Male and female patients of childbearing age have negative pregnancy test results and agree to take contraceptive measures;
  • 4.After treatment with standard dose of ACEI or ARB for more than 3 months, the quantitative results of 24-hour proteinuria were still between 1.0 and 6.0 g;
  • 5.EGFR >60 ml/min/1.73 m^2;
  • 6.Agrees to voluntarily participate in the study and signs an informed consent form.

排除标准

  • 1.Glucocorticoids or other immunosuppressants have been used in the past 6 months;
  • 2.Clinical evidence of secondary membranous nephropathy (tumors, drugs, other autoimmune diseases such as systemic lupus erythematosus, etc.);
  • 3.Complicated with chronic liver disease, myocardial infarction, stroke, uncontrollable hypertension and diabetes, malignant tumor;
  • 4.Known allergy to tripterygium wilfordii polyglycosides or contraindications for use;
  • 5.Female patients who are pregnant (or intend to be pregnant within half a year), breastfeeding or unwilling to take contraceptive measures;
  • 6.Life expectancy is less than 6 months;
  • 7.Are currently participating or have participated in other clinical trials within 3 months;
  • 8.Refuse to sign an informed consent form or are unable or unwilling to comply with a research protocol approved by the researcher;
  • 9.The researchers believe that it is not suitable to participate in other situations of this study.

研究者

发起方
Department of Nephrology, Sichuan Provincial People's Hospital

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