Westlake Sailing Cohort: Dynamic Change of Human Microbiome During Sailing
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 17
- 试验地点
- 1
- 主要终点
- Gut microbial abundant change
研究概览
简要总结
Little is known about the dynamic change of human microbiome in different body sites including skin, mouth and gut during sailing. The present study aims to reveal the change of human microbiome in response to the sailing environment in a 1-month period, and its implication for human health.
详细描述
This study will recruit a number of participants who are going to sail for mariana trench from Shenzhen, China. Characteristics of the participants will be described by a series of index of stool, urine, skin microbiota and tongue coating. All the biospecimen will be collected before and during the voyage. Stool at the 2nd, the 4th and the 12th week after the voyage and blood sample at the baseline will also be collected. Participants' mood states, health-related quality of life, fatigue score and sleep quality will be investigated with questionnaires throughout the 1-month period. Participants are asked to record diseases and symptoms, if any, when sailing. All the data will be used to analyse how microbiota change and be involved in human health during a voyage.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Willingness and capability to complete the study protocol
排除标准
- •Inability or unwillingness to approved to provide informed consent.
- •Women who are pregnant or lactating.
结局指标
主要结局
Gut microbial abundant change
时间窗: Day 1, day 10, day 16, day 23, day 28
Gut microbial communities and their abundant features will be analysed based on shotgun metagenomic sequencing.
Tongue coating microbial abundant change
时间窗: Day 1, day 10, day 16, day 23, day 28
Tongue coating microbial communities and their abundant features will be analysed based on shotgun metagenomic sequencing.
次要结局
- Health-related quality of life change over the one-month sailing(Day 1, day 30)
- Fatigue score change(Day 1, day 10, day 16, day 23, day 30)
- Weight change(Day 1, day 10, day 16, day 23, day 28)
- Blood pressure change(Day 1, day 10, day 16, day 23, day 28)
- Mood states change over 4 weeks(Day 1, day 10, day 16, day 23, day 30)
- Sleep quality change over the one-month sailing(Day 1, day 30)
- Short-chain fatty acids change(Day 1, day 10, day 16, day 23, day 28)
- Skin microbial abundant change(Day 1, day 10, day 16, day 23, day 28)