The Effects of Music Listening on Intra-operative Anxiety in Patients Undergoing Awake Deep Brain Stimulation for Movement Disorders.
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Movement Disorders
- Sponsor
- Darlene A. Lobel, MD
- Enrollment
- 10
- Locations
- 1
- Primary Endpoint
- Cortisol Response
- Status
- Completed
- Last Updated
- 8 years ago
Overview
Brief Summary
This study aims to demonstrate that music listening in patients undergoing awake deep brain stimulation reduces subjective and objective measures of anxiety. Furthermore, the investigators aim to demonstrate that music may alter neuronal firing patterns based on the type of music played and the location in the brain.
Detailed Description
While conscious neurosurgical interventions are generally well-tolerated, they often cause some measure of pain and anxiety. Patients have been reported to suffer from recurring distressing recollections of, or dreams about, the surgery and other post-operative, Post-Traumatic Stress Disorder-like sequelae. High anxiety during surgery correlates with post-operative psychological disturbances. Notably, listening to music reduces anxiety in patients undergoing awake surgical procedures. Nonetheless, DBS is typically performed without music because ambient noise typically interferes with interpretation of neuronal recordings. Recording objective and subjective measures of stress during DBS provides a unique opportunity to determine the effect of music on intra-operative patient anxiety levels in patients listening to music compared to non-music listening control patients. The investigators hypothesize that playing music will improve intra-operative anxiety as measured by objective and subjective measures of stress, including blood pressure, heart rate, cortisol levels and anxiety questionnaires. Additionally, previous data in the investigator's lab has demonstrated that the subthalamic nucleus (STN) responds to melodic music by decreasing the average frequency of neuronal firing. The investigator's pilot study also suggests that STN and thalamic neurons respond differently to melodic music; the neurons in the STN increase synchrony of firing, while neurons in the thalamus decrease synchrony of firing over the course of the music clip. The investigators, therefore, aim to characterize the neuronal firing pattern changes in patients undergoing awake DBS procedures in greater detail, drawing from a larger sample size.
Investigators
Darlene A. Lobel, MD
Principal Investigator
The Cleveland Clinic
Eligibility Criteria
Inclusion Criteria
- •STN or VIM targeted DBS surgery, awake DBS surgery
Exclusion Criteria
- •No previous DBS surgeries, no history of deafness
Outcomes
Primary Outcomes
Cortisol Response
Time Frame: one year
Ratio of intra-operative salivary cortisol to pre-operative salivary cortisol in music-listening vs headphones only patients
Secondary Outcomes
- Medication Requirements(one year)
- Blood Pressure(one year)
- Post-operative Recall Questionnaire(one year)