Population pharmacokinetic and pharmacodynamic modeling of propofol in underweight patients under general anesthesia

Not Applicable

Recruiting

• Conditions: Not Applicable

• Registration Number: KCT0001760
• Lead Sponsor: Asan Medical Center

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 11 March 2019

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

1. 20 yr < age <65 yr
2. BMI (body mass index) < 18.5 (kg/m2)
3. Hemoglobin > 9 g/dl
4. Patients who signed a written informed consent form

Exclusion Criteria

1-1. Patients with severely impaired respiratory function or respiratory depression status
1-2. Patients with convulsive disorders, head injury, shock, a reduced level of consciousness of uncertain origin, intracranial lesions or increased intracranial pressure, or in patients with severe hepatic impairment
1-3. Patients who are concurrently taking other CNS depressants that may cause respiratory depression, hypotension, profound sedation or potentially result in coma
1-4. Clinically significant impairment of cardiovascular, respiratory and renal function
2. Patients with known hypersensitivity to intervention treatments (propofol) or to any of the excipients
3. Patients who are considered by the investigator to be unsuitable to participate in the study for any other reason not mentioned in the inclusion and exclusion criteria.

Study & Design

• Study Type: Interventional Study
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
voluem of distribution, clearance

Secondary Outcome Measures

Name	Time	Method
Area ynder the curve