Identification of Risk Factors for Alteration of the Cellular-arterial Gradient of CO2

• Conditions: Mechanical Ventilation; Prehospital Capnography Monitoring

• Registration Number: NCT04489615
• Lead Sponsor: University Hospital, Angers

Brief Summary

Monocentric, prospective, observational and descriptive study on the evaluation of risk factors for alteration of the alveoarterial gradient of CO2 in pre-hospital patients, intubated and then ventilated in an invasive manner; and their impact on intra-arterial fatehospital.

Detailed Description

Not available

Study Timeline

• Study Start: 2020-06-03
• Study First Submitted: 2020-07-23
• Study First Submitted QC: 2020-07-23
• Study First Posted: 2020-07-28
• Status Verified: 2020-11
• Last Update Submitted: 2020-11-30
• Last Update Posted: 2020-12-02
• Primary Completion: 2021-04-01
• Study Completion: 2021-06-01

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 200

Inclusion Criteria

• 18 years of age,
• Endotracheal intubation in pre-hospital and mechanical ventilation,
• Monitoring of Etco2 in pre-hospital settings

Exclusion Criteria

• Identification of a chest wound blowing during pre-hospital care,
• No technical possibility for performing or analysing arterial sampling,
• Death during pre-hospital care,
• A person who has objected to the processing of his data for research at minimal risk and constraints (category 2) or for research on data, as well as persons subject to legal protection measures.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
identification of risks factors for alteration of the cellular arterial gradient of CO2 in Pre hospital patients	from january 2020 to april 2021	The main objective is therefore to determine the main risk factors to observe an alteration of the alveoarterial gradient in CO2, at the hospital care (fixed at 10 mmHg).

Secondary Outcome Measures

Name	Time	Method
Time of hospital admission	from january 2020 to april 2021	the prognosis of the finding of an altered alveocapillary gradient on the time of hospital admission
length of mecanical ventilation	from january 2020 to april 2021	the prognosis of the finding of an altered alveocapillary gradient on the duration of ventilation
Acute respiratory distress syndrom (ARDS)	from january 2020 to april 2021	the prognosis of the finding of an altered alveocapillary gradient on the occurrence of ARDS
Length of stay	from january 2020 to april 2021	the prognosis of the finding of an altered alveocapillary gradient on the length of stay
Intrahospital mortality	from january 2020 to april 2021	prognostic evidence of altered alveocapillary gradient on intrahospital mortality
Occurence of pneumonia	from january 2020 to april 2021	the prognosis of the finding of an altered alveocapillary gradient on the occurrence of pneumonia
Intrahospital mortality (subpopulation of traumatized patients which had suffered from intracranial hypertension	from january 2020 to april 2021	prognostic evidence of altered alveocapillary gradient, onset of an episode of intracranial hypertension, and intrahospital survival of severely traumatized patients (GCS \< 9).

Trial Locations

Locations (1)

Quentin Carraro; 🇫🇷 Angers, France