Investigation on the effectiveness and safety of lipid-lowering treatments in patients with familial hypercholesterolemia (FAME: Familial Hypercholesterolemia Expert Forum Trial) - Familial Hypercholesterolemia Expert Forum Trial (FAME)

Osaka University Graduate School of Medicine0 个研究点目标入组 769 人开始时间: 2010年2月19日最近更新: 2023年10月17日

适应症

试验速览

阶段: 4 期
状态: 已完成
发起方: Osaka University Graduate School of Medicine
入组人数: 769

研究概览入排标准研究者记录与标识符相似试验

研究概览

简要总结

762 heterozygous and 7 homozygous FH patients were enrolled. CAD was recorded in 23% of patients. Patients without CAD with LDL-C < 100mg/dL, 12.3% and those with CAD with < 70 mg/dL, 1.8%. Male gender, age > 40, FH score < 20, hypertension, and sibling CAD were significantly positively associated with CAD. Male gender, CAD at the baseline, and parental CAD were related to the development of atherosclerotic cardiovascular disease events.

研究设计

研究类型: Observational

入排标准

年龄范围: ot applicable 至 ot applicable（—）
性别: All

入选标准

未提供

排除标准

•1) Patients whose serum triglyceride level is over 400 mg/dl at the time of registration should be excluded. 2) Patients who are suffering from severe liver dysfunction (acute phase and decompensated cirrhosis) 3) Patients with dyslipidemia who are suffering from the following diseases (1) hypothyroidism (2) pancreatitis 4) Patients with uncontrolled diabetes mellitus, whose HbA1c level is over 9%. 5) Patients who are pregnant, suckling or likely to be pregnant. 6) Patients who are judged by the doctor to be improper to be enrolled in this study.

研究者

发起方

Osaka University Graduate School of Medicine

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