The Effect of Cataract Extraction on the Contractility of Ciliary Muscle

Not Applicable

• Conditions: Cataract; Presbyopia
• Interventions: Other: UBM with pilocarpine in presbyopia

• Registration Number: NCT00624039
• Lead Sponsor: Samsung Medical Center

Brief Summary

The purpose of this study is to investigate the changes in the pilocarpine-induced ciliary body movement before and after cataract extraction in order to determine the effect of lens sclerosis on the ciliary muscle contractility.

Detailed Description

The functional changes in the ciliary body in presbyopia are not only important in a study of the mechanism for presbyopia but are also a key to various procedures or devices used to restore accommodation. Therefore, it is becoming increasingly important to quantify the in vivo accommodative changes in the aging ciliary muscle with and without a lens. We are going to evaluate the changes in the pilocarpine-induced contractility of the ciliary muscle in eyes with presbyopia before and after cataract extraction using ultrasound biomicroscopy (UBM).UBM will be performed with and without instilling 2 % pilocarpine, as well as before and 2 months after cataract extraction. Images of the ciliary body will be compared visually using Adobe Photoshop 7.0.

Study Timeline

• Status Verified: 2006-05
• Study Start: 2006-05
• Study First Submitted: 2008-02-18
• Study First Submitted QC: 2008-02-18
• Last Update Submitted: 2008-02-18
• Study First Posted: 2008-02-26
• Last Update Posted: 2008-02-26
• Primary Completion: 2008-03
• Study Completion: 2008-03

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 15

Inclusion Criteria

• Age : same or more than 55 years
• Patients with senile cataract who are going to get cataract surgery

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Exclusion Criteria

• Age : less than 55 years
• Previous ocular disease other than cataract.

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
1	UBM with pilocarpine in presbyopia	ultrasound biomicrocopic examinations and pilocarpine instillation

Primary Outcome Measures

Name	Time	Method
ultrasound biomicroscopic findings (ciliary body axial length)	2 months before and after surgery

Trial Locations

Locations (1)

Samsung Medical Center; 🇰🇷 Seoul, Korea, Republic of