Impact of the Introduction of the MELD Score to Prioritize the Waiting List on Survival, Blood Losses, And Transfusion Requirement for 1000 Consecutive Liver Transplantations, Observational Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 1,000
- 试验地点
- 1
- 主要终点
- Survival;
研究概览
简要总结
The goal of this observational study was to evaluate the impact of the adoption of the MELD system to prioritize patients on the waiting list for OLT on survival for 1000 consecutive liver transplantations. Survival was evaluated on the waiting list, one month, and one year after the transplantation. Another goal was to look at blood losses and transfusion requirement after the adoption of the MELD score. The hypothesis was the MELD system will ameliorate the survival rate on the waiting, but the post-OLT will be worse. Blood losses and transfusions could be worse with the MELD system.
详细描述
IMPACT OF THE INTRODUCTION OF THE MELD SCORE TO PRIORITIZE THE WAITING LIST ON SURVIVAL, BLOOD LOSSES, AND TRANSFUSION REQUIREMENT FOR 1000 CONSECUTIVE LIVER TRANSPLANTATIONS, OBSERVATIONAL STUDY
INTRODUCTION
Orthotopic liver transplantation (OLT) has been classically associated with coagulation defects, blood loss, and the need for massive blood product transfusions .
Transfusion of blood products may contribute to morbidity and mortality. Ironically, one third of patients for OLT had acquired their diseases through transfusion of blood products.
The Child-Turcotte score was developed to predict complications for Porto-cave shunt surgery. This classification was used after to prioritize patients on the waiting for OLT. This classification which includes 3 subjective variables (nutrition, encephalopathy, ascites control) was improved by replacing nutrition by the international normalized ratio (INR) .
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 17 Years 至 70 Years（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients for a liver transplantation at the investigators' institution
排除标准
- 未提供
结局指标
主要结局
Survival;
时间窗: one year
次要结局
- transfusion of blood products(Per0operatively)
- Bleeding(Per-operatively)