Comparison of cognitive recovery using propofol or dexmedetomidine infusion on patients undergoing elective surgery under general anesthesia
试验速览
- 阶段
- 2/3 期
- 状态
- 尚未招募
- 发起方
- 入组人数
- 60
- 试验地点
- 1
研究概览
简要总结
Introduction: Postoperative cognitive dysfunction (POCD) is a common complication following general anaesthesia, impacting patient’s cognitive recovery. Propofol and Dexmedetomidine are widely used anaesthetic agents with differing pharmacological profiles that may influence cognitive outcomes differently.
Aims and Objectives: To compare cognitive recovery in patients receiving dexmedetomidine versus propofol infusion during elective surgery under general anaesthesia.
Methodology: This prospective, randomized, double-blinded study will include 60 ASA I-II patients aged more than 65yr undergoing elective non-neurological, non-cardiac surgery. Patients will be randomized to receive either dexmedetomidine (0.3–0.7 mcg per kg per hour) or propofol (100–200 mcg per kg per min) infusion for maintenance of anaesthesia. These will be used as adjuvants to General anaesthesia. The depth of anaesthesia will be monitored via BIS to maintain values between 40 and 60. Cognitive function will be assessed using the Montreal Cognitive Assessment (MoCA) at baseline and 6, 24 and 48hours postoperatively. Hemodynamic parameters and adverse effects such as bradycardia and hypotension will be recorded.
Outcome/Significance: This study is significant as it aims to provide clear evidence comparing the effects of dexmedetomidine and propofol on cognitive recovery after elective surgery, addressing gaps in regional data. Its findings can guide anaesthetic choices to enhance patient safety, optimize postoperative cognitive function, and reduce anaesthesia-related complications.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 盲法
- Participant and Outcome Assessor Blinded
入排标准
- 年龄范围
- 65.00 Year(s) 至 90.00 Year(s)（—）
- 性别
- All
入选标准
- •ASA Physical Status I or II.
- •Elective non-neurological, non-cardiac surgeries lasting 1–3 hours.
- •3.Preoperative MoCA scores within normal limits.
- •4.Patients able to read, write, and understand the vernacular language Punjabi or English.
- •5.Patients having primary level education.
排除标准
- •1.Pre-existing cognitive dysfunction (MoCA less than 26).
- •2.Patient on Beta blockers 3.Low heart rate 4.History of neurological or psychiatric illness.
- •5.Chronic alcohol or drug abuse.
- •6.Hearing or visual impairments affecting test performance 7.Emergency surgeries.
研究者
Dr Geetanjali Pushkrana
Sri Guru Ram Das Institute of Medical Sciences and Research