Randomized clinical trial on efficacy and tolerability of intra-articular clodronate compared to placebo in knee osteoarthritis - CLIA
- Conditions
- Knee osteoarthritisMedDRA version: 9.1Level: LLTClassification code 10048794Term: Gonarthrosis
- Registration Number
- EUCTR2009-012956-26-IT
- Lead Sponsor
- AZIENDA OSPEDALIERA ISTITUTI OSPITALIERI DI VERONA
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Recruiting
- Sex
- All
- Target Recruitment
- Not specified
Inclusion Criteria
Men and women aged 50 to 75 years with knee osteoarthritis according to ACR criteria, radiologically confirmed, with a Kellgren/Lawrence grade of 2 and 3; starting spontaneous pain >= 40 on a VAS of 0 to 100 and functional disability >=2 on a scale of 1 to 4; informed consent.
Are the trial subjects under 18? no
Number of subjects for this age range:
F.1.2 Adults (18-64 years) yes
F.1.2.1 Number of subjects for this age range
F.1.3 Elderly (>=65 years) yes
F.1.3.1 Number of subjects for this age range
Exclusion Criteria
Osteoarthrtis secondary to other joint diseases, corticosteroid therapy during previous 30 days or NSAIDs therapy during previous 4 days; previous major surgery in the kenn, or arthroscopy within previous 6 months.
Study & Design
- Study Type
- Interventional clinical trial of medicinal product
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method