COMPARING EFFICACY OF AZITHROMYCIN, DOXYCYCLINE, AND COMBINATION THERAPY IN TREATMENT OF COMPLICATED SCRUB TYPHUS: A TRIPLE BLINDED RANDOMIZED CONTROLLED TRIA

AIIMS Rishikesh0 个研究点目标入组 0 人开始时间: 待定最近更新: 2021年11月24日

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•Patients within the age defined criteria who presented with severe scrub typhus (reduced level of consciousness, clinical jaundice, shock, vomiting severe enough to disallow the use of oral medications, clinical or radiological evidence of lung involvement, clinical evidence of meningitis/encephalitis or the need of a lumbar puncture, any other syndrome that in the opinion of the admitting doctor constitutes severe scrub typhus (reason stated by the treating physician), ability to stay in the hospital for the duration of treatment (duration of 7 days) and a high likelihood of completing at least 4 weeks follow up, negative pregnancy test for all women of childbearing age-as from history and/or negative urinary pregnancy test

•participants who are contraindicated to doxycycline and azithromycin or both, patients who had taken chloramphenicol, tetracycline, or ciprofloxacin during the previous 48 hours, pregnancy or breastfeeding, long term use of immunosuppressant (eg. steroids, chemotherapy, TNF-inhibitors) and use of HAART for HIV patients, have a non-infectious cause of pulmonary infiltrates, have or be at risk for major cardiac events or dysfunction, received within 7 days before enrollment of class Ia or Class III anti-arrhythmic medication, end-stage renal disease (stage 5)

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