A randomized controlled study to compare the effects of angiotensin II type 1 receptor blockers (telmisartan vs candesartan vs valsartan) on the markers of cardiovascular risk in hypertensive patients with type 2 diabetes mellitus
Not Applicable
Completed
- Conditions
- Hypertension with type 2 diabetes mellitus
- Registration Number
- JPRN-UMIN000001689
- Lead Sponsor
- Department of Endocrinology and DiabetesNagoya University Graduate School of Medicine
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- All
- Target Recruitment
- 300
Inclusion Criteria
Not provided
Exclusion Criteria
1. Patients being prescribed pioglitazone 2. Patients being treated with insulin 3. Patients with severe hepatic dysfunction 4. Patients with severe renal dysfunction 5. Patients with severe infection or severe injury 6. Patients requiring operative treatment 7. Patients with a past history of hypersensitiveness to these drugs 8. Pregnant and probably pregnant patients 9. Other patients judged as being inappropriate for the subjects of the study investigators
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1. changes in adipocytokines 2. changes in high-sensitivity CRP 3. changes in PAI-I
- Secondary Outcome Measures
Name Time Method 1. changes in blood pressure levels measured on an outpatient basis 2. changes in blood pressure levels at home 3.changes in HOMA-R(fasting glucose, fasting insulin) 4.changes in HbA1c 5.changes in serum lipids levels (cholesterol, triglycerides, HDL cholesterol, FFA) 6.changes in urinary albumin levels