Influence of Single Nucleotide Polymorphisms on Disease Susceptibility and Gefitinib-induced Toxicities in Lung Cancer Patients
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- This study aims to provide an overview of the association of NAT2 gene polymorphisms towards
研究概览
简要总结
In our study, we intend to collect the blood samples of controls (without lung cancer) and lung cancer patients and record the associated demographic and clinical details.
The lung cancer susceptibility and pharmacogenomic analysis will be conducted using these samples. We intend to look at the single nucleotide polymorphism of CYP2D6 gene which is associated with Gefitinib induced toxicity
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18.00 Year(s) 至 80.00 Year(s)（—）
- 性别
- All
入选标准
- •Lung cancer patients (both males and females) with EGFR positive mutation.
- •Patients who are 18 years and above.
- •Patients who are willing to give informed consent.
- •Controls: Individuals (18 years and above) without lung cancer who are willing to take part in the study.
排除标准
- •HIV positive patients.
- •Patients with seriously ill conditions or clinically unstable patients.
结局指标
主要结局
This study aims to provide an overview of the association of NAT2 gene polymorphisms towards
时间窗: 1 year
lung cancer susceptibility in a tertiary care hospital. The current study explores the association of CYP2D6 gene polymorphisms with gefitinib-induced toxicities in lung cancer patients.
时间窗: 1 year
次要结局
- Current study could help in deriving individualized drug dosing strategies for improving treatment outcomes, reducing ADRs, and therapeutic compliance. This would pave the way for large-scale cancer pharmacogenomic studies to revitalize precision medicine for Indian lung cancer patients(1 year)
研究者
Pratheek J
Manipal College of Pharmaceutical Sciences, MAHE, Manipal