Detection of Small Fiber Neuropathy Using Skin Properties
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 400
- 试验地点
- 1
- 主要终点
- Diagnostic accuracy of image processing
研究概览
简要总结
Small fiber neuropathy affects millions of peoples worldwide. The neuropathy is causing disabling burning pain and dysautonomia such as dizziness with standing, brain fog, fatigue, constipation, too much or too little sweating. The detection of nerve damage is complicated and not widely available; it requires either skin biopsy or specialized equipment and training. This project utilizes the mathematical processing of skin pictures for the purpose to extract the statistical features related to loss of small fibers. This approach can improve the availability of diagnosis of small fiber neuropathy.
详细描述
Small fiber neuropathy, including cardiovascular diabetic neuropathy, affects millions of peoples worldwide. The neuropathy is causing disabling burning pain and dysautonomia such as dizziness with standing, brain fog, fatigue, constipation, urinary problems and cold or hot intolerance. Early and accurate diagnosis of neuropathy is essential for correct treatment. Available diagnostic methods are either invasive such as skin biopsy or available only in few specialized centers. This project addresses the limited availability of small fiber neuropathy detection.
The project utilizes utilize specialized image processing of skin pictures for the purpose to extract the statistical features that are related to loss of small fibers. The accuracy of the diagnosis verified using skin biopsies.
This approach can improve the availability of diagnosis of small fiber neuropathy.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients with age 18 year or older
- •Patients that sign the informed consent form to participate in this study
- •Patients completed the autonomic testing with skin biopsies
排除标准
- •Patients with significant hairs at the legs that will cover the skin
- •Any dermatological disorder that can affect the skin composition
- •The use of skin lotion
结局指标
主要结局
Diagnostic accuracy of image processing
时间窗: 2 years
The diagnostic accuracy of image processing will be evaluated by using the skin biopsy as a reference.
次要结局
未报告次要终点
研究者
Peter Novak
Director, Autonomic Laboratory
Brigham and Women's Hospital