Effect of methyl donor supplementation in treatment of overweight and obesity
Early Phase 1
Recruiting
- Conditions
- Overweight and obesity.Overweight and obesity
- Registration Number
- IRCT20180528039881N1
- Lead Sponsor
- Shiraz University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 44
Inclusion Criteria
People with overweight and obesity (BMI=25) whose serum homocysteine levels are higher than normal (15 mcmol / L), or at the highest levels of homocysteine serum levels
The age range between 20-60 years
Residence in Shiraz
Ability to understand the goals of study and provide informed written consent
The desire to participate in the study
Exclusion Criteria
History of any severe systemic disease, endocrine or metabolic disorders
Using any type of lipid and glucose lowering drug
Taking any type of food supplement and herbal remedies in the last 6 months
History of any allergy, intolerance, or adverse drug reaction to the supplements studied
Pregnancy and lactation
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Homocysteine. Timepoint: The beginning and the end of the study. Method of measurement: serum homocysteine level.
- Secondary Outcome Measures
Name Time Method Anthropometric measurements. Timepoint: The beginning, the forth week and the end of the study. Method of measurement: stadiometer, mechanical scales and body analyzer.;Blood suger. Timepoint: The beginning and the end of the study. Method of measurement: serum blood suger.;Lipid profile. Timepoint: The beginning and the end of the study. Method of measurement: Serum Lipid Profile.;The beginning and the end of the study. Timepoint: ????????? ????? ????? ?????. Method of measurement: Serum leptin and gherelin.;Leptin gene expresion. Timepoint: The beginning and the end of the study. Method of measurement: Real time- PCR mehthod.