Effects of meals with varying levels of anti-inflammatory compounds on circulating cytokines in overweight and obese adults: A randomised controlled postprandial pilot study
试验速览
- 阶段
- 未知
- 状态
- 已完成
- 发起方
- 入组人数
- 12
研究概览
简要总结
Reduction in subclinical inflammation is a potential target for chronic disease prevention, and pro-inflammatory effects of foods are observed following consumption of a single high fat meal. This study explores whether manipulation of the anti-inflammatory potential of meals, using the Dietary Inflammatory Index (DII), alters postprandial levels of circulating inflammatory markers (plasma levels of IL-6, IL-1ß, TNF-a and IL-10) in adults above a healthy weight. In a randomised controlled, crossover design, 12 adults aged between 50 and 75 years, who were above a healthy weight, consumed three meals that were matched for energy (2.2 MJ) and designed to have a low (-6.24), moderate (-2.76) or high (+9.36) Dietary Inflammatory Index (DII) score, after an overnight fast. Fasting and postprandial blood samples were collected over five hours and analysed for IL-6, IL-1ß, TNF-a and IL-10. Postprandial changes in these measured inflammatory markers were not different between the three test meals.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomised controlled trial
- 主要目的
- Prevention
- 盲法
- Open (masking not used)
入排标准
- 年龄范围
- 50 Years 至 75 Years（—）
- 性别
- All
入选标准
- •Eligible participants were men > 50 and < 75 years or post-menopausal women, with a body mass index (BMI) > 25 kg/m2.
排除标准
- •Diagnosis of a chronic disease (such as CVD or T2DM), known allergies/intolerances to study foods, loss of > 10% total body weight in the 6 months preceding the study, smokers, history of drug or alcohol addiction, and use of anti-inflammatory medications such as aspirin, steroids or non-steroidal anti-inflammatory drugs.