Inflammatory responses to meals with varying levels of anti-inflammatory potential: a randomised control pilot study in adults above a healthy weight

Not Applicable

Completed

• Conditions: Postprandial inflammation; Diet and Nutrition - Obesity; Metabolic and Endocrine - Diabetes; Metabolic and Endocrine - Normal metabolism and endocrine development and function

• Registration Number: ACTRN12620000525987
• Lead Sponsor: Dr Aimee Dordevic

Brief Summary

Reduction in subclinical inflammation is a potential target for chronic disease prevention, and pro-inflammatory effects of foods are observed following consumption of a single high fat meal. This study explores whether manipulation of the anti-inflammatory potential of meals, using the Dietary Inflammatory Index (DII), alters postprandial levels of circulating inflammatory markers (plasma levels of IL-6, IL-1ß, TNF-a and IL-10) in adults above a healthy weight. In a randomised controlled, crossover design, 12 adults aged between 50 and 75 years, who were above a healthy weight, consumed three meals that were matched for energy (2.2 MJ) and designed to have a low (-6.24), moderate (-2.76) or high (+9.36) Dietary Inflammatory Index (DII) score, after an overnight fast. Fasting and postprandial blood samples were collected over five hours and analysed for IL-6, IL-1ß, TNF-a and IL-10. Postprandial changes in these measured inflammatory markers were not different between the three test meals.

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Completion: 2018-11-23
• Study Start: 2020-04-29
• Last Update Posted: 11 May 2020

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 12

Inclusion Criteria

Eligible participants were men > 50 and < 75 years or post-menopausal women, with a body mass index (BMI) > 25 kg/m2.

Exclusion Criteria

Diagnosis of a chronic disease (such as CVD or T2DM), known allergies/intolerances to study foods, loss of > 10% total body weight in the 6 months preceding the study, smokers, history of drug or alcohol addiction, and use of anti-inflammatory medications such as aspirin, steroids or non-steroidal anti-inflammatory drugs.

Study & Design

• Study Type: Interventional
• Study Design: Not specified